Results 141 to 150 of about 2,023,324 (272)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Chinese Acrobatics, an Old-Time Brewery, and the “Much Needed Gap”: The Life of Mathematical Reviews

open access: yes, 2008
has been an important part of the AMS and the mathematical sciences community. Sweeping in scope, solemn in tone, and deadly accurate, MR has led multitudes to what they were searching for in the literature of mathematics and allied areas. Mathematicians
Mathematical Reviews
core  

Use and characteristics of free/libre and open source electronic health records: an overview of reviews. [PDF]

open access: yesJAMIA Open
Thives Mello A   +11 more
europepmc   +1 more source

On Reviewing the Reviewers

open access: yesAnnals of Emergency Medicine, 1999
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reseñas / Reviews núm. 9

open access: yesCultura, Lenguaje y Representación, 2011
Reseñas Reviews
doaj  

Home - About - Disclaimer - Privacy