Results 151 to 160 of about 2,023,324 (272)

Factors associated with response to patient-reported outcome measures: a systematic review of systematic and scoping reviews, and meta-analyses. [PDF]

Qual Life Res
Peters ST, Rutten J, van Kooij YE, Selles RW, Slijper HP, Hand-Wrist Study Group, Wouters RM.   +6 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reseñas / Reviews núm. 6

Cultura, Lenguaje y Representación, 2009
Reviews Reseñas
doaj  

Factors affecting well-being among retired older adults: A protocol for an umbrella review. [PDF]

PLoS One
Yasin YM, Al-Hamad A, Metersky K, Read E, Witherspoon R.   +4 more
europepmc   +1 more source

Review: Book Review [PDF]

The Computer Journal, 1969
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The clinical effectiveness of trastuzumab for breast cancer: a systematic review

Health Technology Assessment, 2002
R. Lewis, A.-.M Bagnall, C. Forbes, E. Shirran, S. Duffy, J. Kleijnen, R. Riemsma, G. ter Riet   +7 more
doaj   +1 more source

Therapeutic strategies for idiopathic granulomatous mastitis: an umbrella review of systematic reviews and meta-analyses. [PDF]

Front Med (Lausanne)
Yao S, Xu L.
europepmc   +1 more source

Review: Book Review [PDF]

The Computer Journal, 1968
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source