Results 201 to 210 of about 14,475,028 (324)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Effectiveness of digital health interventions in influencing the primary prevention of non-communicable diseases: protocol for an umbrella review. [PDF]

BMJ Open
Jeleff M, Dorner TE, Ban M, Schön M, Lischka C, Lichtenegger K, Dür M, Hochwarter S, Feichtner F, Haider S.   +9 more
europepmc   +1 more source

Peer review reviewed [PDF]

Nature, 2002
openaire   +2 more sources

Modeling Market Volatility in Emerging Markets: The case of Daily Data in Amman Stock Exchange 1992-2004 [PDF]

This paper attempts to investigate the volatility of the Jordanian emerging stock market using daily observations from Amman Stock Exchange Composite Index (ASE) for the period from January 1, 1992 through December 31, 2004.
AL-KHOURI, Ritab, ROUSAN, Raya
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Reverse spin bias: preliminary observations of reporting bias in medical systematic reviews. [PDF]

Res Integr Peer Rev
O'Leary R, La Rosa GRM, Polosa R.
europepmc   +1 more source

Review: Book Review [PDF]

The Computer Journal, 1968
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Review: Book review [PDF]

The Computer Journal, 1961
openaire   +5 more sources

Sexual Health After Neurological Disorders: A Comprehensive Umbrella Review of Treatment Evidence. [PDF]

Med Sci (Basel)
Manuli A, Calderone A, Latella D, Quattrini F, Pucciarelli G, Calabrò RS.   +5 more
europepmc   +1 more source