Results 91 to 100 of about 901,372 (249)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Revisión narrativa acerca de la asociación entre la enfermedad venosa crónica y la diabetes mellitus

open access: yesRevista de la Alad. Asociación Latinoamericana de Diabetes
La enfermedad venosa crónica y la diabetes mellitus comparten numerosos aspectos clínicos y fisiopatológicos. Se reconoce una asociación entre las complicaciones microvasculares y macrovasculares en los individuos con diabetes mellitus, y se postula el concepto de enfermedad panvascular diabética, en el cual la macroangiopatía y la microangiopatía ...
José L. Salazar-García   +4 more
openaire   +1 more source

Aneurisma de arteria renal durante trasplante: presentación de caso y revisión de la literatura

open access: yesRevista Mexicana de Angiolog�a
Los órganos denominados marginales pueden emplearse como opciones seguras para el trasplante de órganos en pacientes en espera de donación, incrementando la tasa de trasplantes, uno de los objetivos dentro de organizaciones dedicadas al trasplante renal. Dentro de la definición se encuentran como opción los riñones con presencia de aneurisma de arteria
Julio O. Reyna-Ortega   +1 more
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Cetoacidosis diabética como un reto para el médico de urgencias: una revisión bibliográfica

open access: yesRevista de Educaci�n e Investigaci�n en Emergencias
La cetoacidosis diabética (CAD) es una complicación aguda común de la diabetes mellitus y altamente mortal que debe tratarse lo más pronto posible para evitar complicaciones. Varias asociaciones como la American Diabetes Association (ADA), la Joint British Diabetes Societies for Inpatient Care y la International Society of Pediatric and Adolescent ...
Eduardo Rodríguez-Puente   +2 more
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Efectividad del ejercicio físico en el control de la hipertensión arterial en adultos: revisión sistemática y metaanálisis

open access: yesRevista Información Científica
Introducción: la hipertensión arterial es la enfermedad cardiovascular más común en los adultos. Existen estudios que sugieren que el ejercicio físico puede ser implementado como terapia y profilaxis de la hipertensión arterial por sus efectos ...
Frank Octavio Valdespino-Mendieta   +2 more
doaj   +1 more source

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