Results 51 to 60 of about 114,282 (294)

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

The mid-term outcomes of mobile bearing unicompartmental knee arthroplasty versus total knee arthroplasty in the same patient

Frontiers in Surgery, 2023
ObjectiveTo compare the mid-term outcomes of unicompartmental knee arthroplasty (UKA) that was performed in one knee and total knee arthroplasty (TKA) performed in the other knee in the same stage.MethodsThis is a retrospective study.
Jinlong Ma, Liang Zhang, Cui Wang, Kuishuai Xu, Zhongkai Ren, Tianrui Wang, Yingze Zhang, Xia Zhao, Tengbo Yu   +8 more
doaj   +1 more source

Combined Management of Meniscus Root Tear and High Tibial Osteotomy: A Surgical Strategy Using 3‐Dimensional Printing

Arthroscopy Techniques, EarlyView.
Abstract Combining high tibial osteotomy with meniscal posterior root repair is technically challenging because of the limited metaphyseal bone stock, the proximity of the transtibial tunnel to the osteotomy site, and the risk of implant conflict or tibial fracture.
Arash Sherafatvaziri, Morad Karimpour, Ghazaleh Moradkhani, Yasaman Ghahremani, Fardis Vosoughi, Alireza Mirzamohamadi, Ramin Shayan‐moghadam   +6 more
wiley   +1 more source

Causes and rates of revision total knee arthroplasty: Local results from Isfahan, Iran

Advanced Biomedical Research, 2015
Background: Knee replacement is one of the most frequently performed surgical procedures in the world. Local data on revision total knee arthroplasty (TKA) are limited.
Mehdi Motififard, Mohamad Pesteh, Mohammad Reza Etemadifar, Somayeh Shirazinejad   +3 more
doaj   +1 more source

Early Tibial Component Fractures in a Cementless, 3D-Printed, Titanium Implant

Arthroplasty Today, 2022
Fracture of the tibial baseplate in total knee arthroplasty is a rare occurrence, particularly in short- and mid-term follow-up. This case series documents the first known report in the literature of fatigue fracture of a cementless, 3D-printed, highly ...
Alan D. Lam, BS, Gavan P. Duffy, MD
doaj   +1 more source

Abduction and adduction malpositioned lateral radiographs cannot be used for proper assessment of the posterior tibial slope

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare medial posterior tibial slope (mPTS) measurements on abduction/adduction malpositioned versus properly positioned lateral knee radiographs within the same patients. We hypothesized that malpositioning would significantly alter mPTS values and potentially change surgical classification at the commonly used 12° threshold for ...
Moses Kamal Dieter El Kayali, Luis Vincent Bürck, Stephen Fahy, Alan Getgood, Clemens Gwinner, Lorenz Pichler   +5 more
wiley   +1 more source

High posterior tibial slope increases graft failure risk but does not impair functional outcomes after primary ACL reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Posterior tibial slope (PTS) has been implicated in anterior cruciate ligament (ACL) graft failure, but its relationship to objective stability and patient‐reported outcomes (PROs) after primary ACL reconstruction (ACLR) remains unclear. The study evaluated whether higher PTS is associated with laximetry, graft survival, and PROs after
Paul Souvik, Maher Ghandour, Ernest Siret, Fabio Sammartino, Piercecchi Antoine, Matthieu Ollivier   +5 more
wiley   +1 more source

Revision of Total Knee Arthroplasty.

Orthopedics & Traumatology, 1995
Out of 670 total knee arthroplasties performed at our institution until 1993, eighteen were followed by revision. The major reasons for revision were loosening, dislocation, and infection.Eight of the eighteen knees were revised using a kinematic rotating hinge. Results using this prosthesis were good following revision.
Esaki, Yoshiharu, Maekawa, Masayuki, Kamo, Yohshi, Tokuhisa, Ginichiroh   +3 more
openaire   +2 more sources

Posterior cruciate ligament involvement leads to inferior outcomes in multiligament knee injuries involving the medial collateral ligament: A systematic review and meta‐analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Multiligament knee injuries (MLKIs) involving the medial collateral ligament (MCL) present unique challenges in surgical management and postoperative rehabilitation. This systematic review and meta‐analysis aimed to evaluate postoperative patient‐reported outcomes in patients with MCL‐involved MLKIs, with a minimum follow‐up of 2 years.
Collin Donald Roy Hunter, Judith Sternbauer, Christian Kammerlander, Johannes Grillari, Ortrun Neuper, Justin J. Ernat, Antonio Klasan   +6 more
wiley   +1 more source

Causes and Clinical Outcomes of Revision Total Knee Arthroplasty

Knee Surgery and Related Research, 2017
Purpose The purpose of this study was to evaluate causes and clinical outcomes of revision total knee arthroplasty (TKA) with a minimum 2-year follow-up.
Dong-Hyun Lee, Seung-Hun Lee, E. Song, J. Seon, Hong-An Lim, Hongyeol Yang   +5 more
semanticscholar   +1 more source