Results 81 to 90 of about 46,483 (290)

3-dimensional pedagogy-the image of 21st century teacher professionalism [PDF]

open access: yes, 2003
With the advent of post-industrialism the work of teachers will surely change dramatically. But how? In this final chapter of the year book, Dorothy Andrews and Frank Crowther draw on the outcomes of a successful school revitalisation project that has ...
Andrews, Dorothy, Crowther, Frank
core  

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

open access: yesAdvanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang   +18 more
wiley   +1 more source

Revitalising primary health care

open access: yesKathmandu University Medical Journal, 1970
doi: 10.3126/kumj.v6i3.1701Kathmandu University Medical Journal (2008), Vol. 6, No.
openaire   +3 more sources

Evaluation of the performance of granular fertilizer boom sprayer through computational fluid-particles-dynamid CFD simulation and scaled-down model analysis [PDF]

open access: yes, 2018
Malaysian Agricultural Research and Development Institute (MARDI) had bought two Japanese made granular fertilizer boom sprayers to test it on Malaysia’s Paddy field.
Eng, Pei Ying
core  

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

open access: yesAdvanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong   +11 more
wiley   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

open access: yesAdvanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu   +8 more
wiley   +1 more source

The life cycle of authenticity: neo-nomadic tourism culture in Kazakhstan [PDF]

open access: yes, 2018
The paper presents the findings related to the stages of life cycle of authenticity where Kazakhstani nomadic culture in a post-Soviet heritage evolves towards tourist consumption.
Tiberghien, Guillaume   +1 more
core   +1 more source

Universal Solvent Escape Strategies for Efficient Curing of Hydrogen‐Bond‐Rich 3D Printing Inks

open access: yesAdvanced Science, EarlyView.
This study developed a new 3D printing method for hydrogen‐bonded polymers by combining solvent replacement, nanoparticles, and optimized printing paths. This allows fast, precise scaffold fabrication. The scaffolds can be easily customized and release therapeutic agents slowly through protonation, enabling personalized bone, blood vessel, and nerve ...
Jie Chen   +11 more
wiley   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

open access: yesAdvanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia   +11 more
wiley   +1 more source

Bosnia and Hercegovina [PDF]

open access: yes, 2001
Bosnia-Hercegovina declared sovereignty and seceded from the residue of the Socialist Federal Republic of Yugoslavia (SFRJ) in October 1991, following similar action, first by Slovenia, then by Croatia and after a plebiscite, boycotted by many ethnic ...
Clarke, Richard
core  

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