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Results 61 to 70 of about 19,008 (268)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao +8 more
wiley +1 more source

Multiple strategies of HSP antimicrobial peptide optimization to enhance antimicrobial activity

Amino Acids
Antimicrobial peptides (AMPs) have caught the attention of researchers over the last couple of years due to their unique membrane lytic mechanism for combating antibiotic resistance, which differs from the molecular targets of traditional antibiotics ...
Xiaozhong Cheng +6 more
doaj +1 more source

Ethical and Frugal Approaches to Animal Experimentation in Bioelectronics and Neural Engineering—An Invertebrate Renaissance?

Advanced Electronic Materials, EarlyView.
Invertebrates are the classic neuroscience models and should make a comeback. Invertebrate organisms can be a more ethical and cost‐effective way to move bioelectronics research forward more rapidly. ABSTRACT The accelerating development of bioelectronic neural interfaces has brought increased attention to ethical considerations surrounding in vivo ...
Eric Daniel Głowacki
wiley +1 more source

Rural revitalization potential and pathway optimization in Qinling poverty-alleviation mountainous areas under community resilience framework [PDF]

Ziyuan Kexue
[Objective] Evaluating the potential of rural revitalization in the new era is a prerequisite for effectively connecting the consolidation of poverty alleviation achievements in poverty-alleviation mountainous areas with rural revitalization. Research on
GUO Yuexi, CHEN Jia, YIN Sha, YANG Xinjun, XIAO Yang
doaj +1 more source

Revitalizing Psychiatric Therapeutics [PDF]

Neuropsychopharmacology, 2013
Despite high prevalence and enormous unmet medical need, the pharmaceutical industry has recently de-emphasized neuropsychiatric disorders as 'too difficult' a challenge to warrant major investment. Here I describe major obstacles to drug discovery and development including a lack of new molecular targets, shortcomings of current animal models, and the
openaire +2 more sources

Implications of Transient Negative Capacitance Effect in Ferroelectric Polarization Dynamics

Advanced Electronic Materials, EarlyView.
Transient voltage artifacts observed during ferroelectric switching are shown to originate from measurement circuitry rather than intrinsic negative capacitance. By correlating switching current, time scale, and series resistance, this work establishes practical design rules for reliable pulse‐switching experiments and circuit integration of ...
Marin Alexe
wiley +1 more source

The Physiological Responses of Tea to pH and Cd Conditions and the Effect of the CsHMA2 on Cd Transport

Plants
Soil acidification in tea (Camellia sinensis L.) gardens leads to nutrient depletion, inhibits the growth of tea plants, reduces tea quality, and activates heavy metals such as cadmium (Cd) in the soil.
Bin Yang +6 more
doaj +1 more source

Investigation of Moisture‐Induced Degradation Mechanisms and a Reviving Strategy for Sulfide‐Based Solid Electrolytes in All‐Solid‐State Composite Cathode

Advanced Energy Materials, EarlyView.
Moisture exposure induces the formation of reductive solid phases on argyrodite Li6PS5Cl, which destabilize Ni‐rich cathodes by extracting lattice oxygen and inducing surface reconstruction. A brief oxygen‐assisted annealing treatment quenches these reductive phases, restores interfacial stability, and enables effective regeneration and reuse of ...
Yujeong Hwang +5 more
wiley +1 more source

The Impact of Land Transfer on the Livelihood Resilience of Rural Households from the Perspective of Farmer Differentiation

Land
The land transfer system is widely regarded as a key institutional arrangement for advancing agricultural modernization and rural transformation. Drawing on the Sustainable Livelihoods Framework (SLF) and from the perspective of farmer differentiation ...
Shuqi Zhu, Yueqin Shen, Zhen Zhu
doaj +1 more source

Revitalizing Rural Areas in Malaysia: A Framework for Economic Revitalization

IOP Conference Series: Earth and Environmental Science, 2019
Abstract Rural, poor and marginalized community often face many challenges in achieving economic equality and attaining socio-economic sustainability, especially among rural communities who have limited sources of income. In countries with emerging economies such as Malaysia, rural populations constitute the majority of citizens.
M F Rashid, I Ngah, S H Misnan
openaire +1 more source

sustainable development
china