Results 61 to 70 of about 6,424 (214)

Revitalizing Psychiatric Therapeutics [PDF]

Neuropsychopharmacology, 2013
Despite high prevalence and enormous unmet medical need, the pharmaceutical industry has recently de-emphasized neuropsychiatric disorders as 'too difficult' a challenge to warrant major investment. Here I describe major obstacles to drug discovery and development including a lack of new molecular targets, shortcomings of current animal models, and the
openaire   +2 more sources

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Revitalizing the “biology” in “chronobiology”

npj Biological Timing and Sleep
Studies of biological timekeeping have now matured from investigations of a fascinating and ubiquitous phenomenon into a discipline with practical applications; the excitement surrounding such translation has been overwhelming, perhaps at the expense of eclipsing further pursuit of basic research.
Johnson, Carl Hirschie, Helfrich-Förster, Charlotte, Hut, Roelof A, Reece, Sarah E, Schwartz, William J.   +4 more
openaire   +1 more source

Green's Functions of Non‐Hermitian Systems at Exceptional Deficiency

Advanced Science, EarlyView.
We analyze the responses of a non‐Hermitian lattice system under the condition of exceptional deficiency (ED), when all bands in the system are formed by exceptional points. Using the frequency domain, we identify novel steady‐state responses that root in the broadband super‐Lorentzian Green's function (GF).
Congwei Lu, Guancong Ma
wiley   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Agricultural Machinery Adoption and Farmers’ Well-Being: Evidence from Jiangxi Province

Agriculture
As a cornerstone of agricultural modernization, agricultural mechanization plays a pivotal role in driving rural revitalization and establishing agricultural competitiveness.
Zhihua Wu, Bing Liao, Qing Fu, Chongyi Qi, Wenmei Liao   +4 more
doaj   +1 more source

A Thirty‐Year Gap: Reviving All‐Nitride Glasses as Processable, High‐Performance Materials

Advanced Science, EarlyView.
Oxygen‐free all‐nitride glasses are revisited in light of new avenues of synthesis, raw material availability, and applications. A semi‐empirical analysis predicts mechanical performance achieving the level of engineering ceramics while maintaining visual transparency, and significant potential regarding optical properties into the infrared spectral ...
Alexis Duval, Tor Grande, Lothar Wondraczek   +2 more
wiley   +1 more source

Comparative metagenomic and untargeted metabolomic analyses reveal gut microbiota and metabolite alterations associated with diarrhea in neonatal Holstein calves in Anhui, China [PDF]

Veterinary World
Background and Aim: Neonatal calf diarrhea remains a major cause of morbidity, mortality, and economic losses in the dairy industry. Although alterations in gut microbial communities have been implicated in calf diarrhea, the interactions between ...
Xing Zhang, Hui Liu, Chaoyue He, Huiyang Chen, Huilin Zhang, Falei Li   +5 more
doaj   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source