Results 71 to 80 of about 184,287 (297)

Urban Policy in the Carter Administration [PDF]

, 2010
Scans literature on the Carter administration's review of urban policy, its recommendations, and the history of spatial distribution analysis of federal outlays.
G. Thomas Kingsley, Karina Fortuny
core  

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Multiple strategies of HSP antimicrobial peptide optimization to enhance antimicrobial activity

Amino Acids
Antimicrobial peptides (AMPs) have caught the attention of researchers over the last couple of years due to their unique membrane lytic mechanism for combating antibiotic resistance, which differs from the molecular targets of traditional antibiotics ...
Xiaozhong Cheng, Yonghuang Zhang, Yan Zhang, Yajun Chen, Jianli Chen, Wei Wang, Guilan Zhu   +6 more
doaj   +1 more source

Revitalizing Labor In Today\u27s World Markets [PDF]

, 2000
[Excerpt] Competitiveness for firms is possible via the high road or low road, or some combination of the two. For a nation, however, if competitiveness means the ability of a country\u27s firms to sell on world markets while contributing to rising ...
Turner, Lowell
core   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Rural revitalization potential and pathway optimization in Qinling poverty-alleviation mountainous areas under community resilience framework [PDF]

Ziyuan Kexue
[Objective] Evaluating the potential of rural revitalization in the new era is a prerequisite for effectively connecting the consolidation of poverty alleviation achievements in poverty-alleviation mountainous areas with rural revitalization. Research on
GUO Yuexi, CHEN Jia, YIN Sha, YANG Xinjun, XIAO Yang
doaj   +1 more source

The Flight of the Black Wolf Squadron [PDF]

, 2012
By 1920, Alaska became economically, politically, and socially stale. Aviation brought a need revitalization to the territory. The Black Wolf Squadron's flight from New York to Nome brought international attention and promised new industries and ...
Widman, Benjamin
core  

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

The Physiological Responses of Tea to pH and Cd Conditions and the Effect of the CsHMA2 on Cd Transport

Plants
Soil acidification in tea (Camellia sinensis L.) gardens leads to nutrient depletion, inhibits the growth of tea plants, reduces tea quality, and activates heavy metals such as cadmium (Cd) in the soil.
Bin Yang, Yao Xiao, Lei Li, Min Shen, Xiaogang Lei, Xujun Zhu, Wanping Fang   +6 more
doaj   +1 more source