Results 111 to 120 of about 438,911 (302)
Brain Sciences, 2019 The genetic relationships between different behaviors used to index the aversive effects of ethanol are unknown. To address this issue, ethanol-induced conditioned place aversion (CPA) was tested in a genetically diverse panel of 15 inbred mouse strains.
Christopher L. Cunningham
doaj +1 more source
International Journal of Artificial Intelligence in Education, 2019 Since the 1960s, researchers have been trying to optimize the sequencing of instructional activities using the tools of reinforcement learning (RL) and sequential decision making under uncertainty. Many researchers have realized that reinforcement learning provides a natural framework for optimal instructional sequencing given a particular model of ...
Shayan Doroudi +2 more
openaire +2 more sources
Interactions between reward and visual statistical learning
, 2020 Vickery, Timothy J.Humans are adept at learning regularities in a visual environment, even without explicit cues to structure and in the absence of instruction—this has been termed “visual statistical learning” (VSL).
Park, Su Hyoun
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
An Update on the Role of Serotonin and its Interplay with Dopamine for Reward
Frontiers in Human Neuroscience, 2017 The specific role of serotonin and its interplay with dopamine (DA) in adaptive, reward guided behavior as well as drug dependance, still remains elusive.
Adrian G. Fischer +3 more
doaj +1 more source
Characterization of reward functions in networks with costs [PDF]
, 2010 In this paper we study network structures in which the possibilities for cooperation are restricted and can not be described by a cooperative game. The benefits of a group of players depend on how these players are internally connected.
Meseguer Artola, Antoni +1 more
core
, 2021 The whitepaper ‘Total Reward Statements: how to maximise the potential?’ is based on a quantitative and qualitative research project by the Centre for Excellence in Strategic Rewards.
Van Steerthem, Angie +2 more
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source