Results 111 to 120 of about 1,394,868 (297)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Extending the Logic IM-SPDL with Impulse and State Rewards [PDF]
, 2007 This report presents the logic SDRL (Stochastic Dynamic Reward Logic), an extension of the stochastic logic IM-SPDL, which supports the specication of complex performance and dependability requirements.
Haverkort, Boudewijn R., Kuntz, Matthias
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
, 2020 Abstract “Reward” explores the personality trait of extraversion in the life of Donald Trump. The chapter begins with an evolutionary account of extraversion’s powerful role in human groups, as a personality trait that enables social actors to attract and hold the attention of others.
openaire +2 more sources
A Local Circuit Model of Learned Striatal and Dopamine Cell Responses under Probabilistic Schedules of Reward [PDF]
, 2007 Before choosing, it helps to know both the expected value signaled by a predictive cue and the associated uncertainty that the reward will be forthcoming. Recently, Fiorillo et al.
Bullock, Daniel, Tan, Can Ozan
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Brain Sciences, 2013 Tobacco smoking is the most frequent form of substance abuse. We provide a review of the neuroadaptive changes evidenced in human smokers with regard to the current neurobiological models of addiction.
Chantal Martin-Soelch
doaj +1 more source
Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents [PDF]
, 2007 BACKGROUND: Functional disturbances in reward-related brain systems are thought to play a role in the development of mood, impulse, and substance abuse disorders. Studies in non-human primates have identified brain regions, including the dorsal / ventral
May, John Christopher
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Reward Model Perspectives: Whose Opinions Do Reward Models Reward?
Proceedings of the 2025 Conference on Empirical Methods in Natural Language ProcessingPublished at EMNLP 2025 under the full author name "Elle"
openaire +3 more sources