Results 91 to 100 of about 1,394,868 (297)
Social Sciences and Humanities OpenFor handling future crises and to give their businesses the best chance of survival it is imperative that owners and managers of SMEs have a comprehensive understanding of the severity of the impact of the crisis itself.
Nokuphila Yvonne Biyela, Reward Utete
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
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Frontiers in PsychologyIntroductionOur recent research has demonstrated that social comparison orientation of ability (SCO-ability) is an antecedent of trait competitiveness (TC), and TC mediates the relation between SCO-ability and domain-specific risk-taking.
Yuqian Wang +5 more
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Learning the specific quality of taste reinforcement in larval Drosophila
eLife, 2015 The only property of reinforcement insects are commonly thought to learn about is its value. We show that larval Drosophila not only remember the value of reinforcement (How much?), but also its quality (What?).
Michael Schleyer +3 more
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Independent circuits in basal ganglia and cortex for the processing of reward and precision feedback
, 2017 In order to understand human decision making it is necessary to understand how the brain uses feedback to guide goal-directed behavior. The ventral striatum (VS) appears to be a key structure in this function, responding strongly to explicit reward ...
Hickey, Clayton +3 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Exploring the relationship between employee engagement and counterproductive work behaviour
Frontiers in PsychologyIntroductionDespite the cumulative increase in counterproductive work behaviour in various organisations which have ripple effects on general organisational performance, little is known on how employee engagement relates to counterproductive work ...
Sphindile Mvuyana +2 more
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eLife, 2015 Value-based decisions could rely either on the selection of desired economic goods or on the selection of the actions that will obtain the goods. We investigated this question by recording from the supplementary eye field (SEF) of monkeys during a ...
Xiaomo Chen, Veit Stuphorn
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Primate amygdala neurons evaluate the progress of self-defined economic choice sequences
eLife, 2016 The amygdala is a prime valuation structure yet its functions in advanced behaviors are poorly understood. We tested whether individual amygdala neurons encode a critical requirement for goal-directed behavior: the evaluation of progress during ...
Fabian Grabenhorst +2 more
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