Results 71 to 80 of about 1,393,287 (284)

Commentary: New View on Treatment of Drug Dependence

Basic and Clinical Neuroscience, 2014
In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function.
Mina Ranjbaran, Hedayat Sahraei
doaj  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Agenda for future business resilience and survival avenues in crisis times: A systematic literature review of the effects of COVID-19 on SMEs’ productivity in South Africa

Social Sciences and Humanities Open
For handling future crises and to give their businesses the best chance of survival it is imperative that owners and managers of SMEs have a comprehensive understanding of the severity of the impact of the crisis itself.
Nokuphila Yvonne Biyela, Reward Utete
doaj   +1 more source

Multi-objective Contextual Multi-armed Bandit with a Dominant Objective

, 2018
In this paper, we propose a new multi-objective contextual multi-armed bandit (MAB) problem with two objectives, where one of the objectives dominates the other objective.
Tekin, Cem, Turgay, Eralp
core   +3 more sources

Distributed Online Learning via Cooperative Contextual Bandits [PDF]

, 2015
In this paper we propose a novel framework for decentralized, online learning by many learners. At each moment of time, an instance characterized by a certain context may arrive to each learner; based on the context, the learner can select one of its own
Tekin, Cem, van der Schaar, Mihaela
core   +2 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Estrogenic control of reward prediction errors and reinforcement learning [PDF]

, 2023
Carla E. M. Golden, Audrey Martin, Daljit Kaur, Andrew Mah, Diana H. Levy, Takashi Yamaguchi, Amy W. Lasek, Dayu Lin, Chiye Aoki, Christine M. Constantinople   +9 more
openalex   +1 more source

Structural Reform in New Zealand: A Review [PDF]

This paper discusses the reasons for the change in economic policy direction adopted in New Zealand in 1984. The paper briefly outlines the economic history of New Zealand in the period from the early 1970's to 1996.
Reward, Peter
core  

The role of gender in the relationship between reinforcement sensitivity and aggression among adolescents [PDF]

, 2020
This study focuses on the relationship between reinforcement sensitivity and aggression according to the combination of forms and functions of aggression (i.e.
Šarić Drnas, Marija
core  

Task-load-dependent activation of dopaminergic midbrain areas in the absence of reward [PDF]

, 2011
Dopamine release in cortical and subcortical structures plays a central role in reward-related neural processes. Within this context, dopaminergic inputs are commonly assumed to play an activating role, facilitating behavioral and cognitive operations ...
Böhler, Nico, Heinze, Hans-Jochen, Hopf, Jens-Max, Krebs, Ruth, Noesselt, Toemme, Schoenfeld, Mircea A, Stoppel, Christian M   +6 more
core   +2 more sources