Results 61 to 70 of about 882,610 (273)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Predicting Performance Of Initial Public Offering (IPO) Firms: Should Human Resource Management (HRM) Be In The Equation? [PDF]
, 1995 Population ecology is utilized to understand the role of human resource management (HRM) in enhancing the performance of initial public offering (IPO) companies.
Andrews, Alice O. +1 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
BetterPoints: Motivating behaviour change using technology-driven incentivisation
Frontiers in Public Health, 2015 Background Conference theme: Using behaviour change theory to create high-quality interventions and products. BetterPoints is a localised behaviour change system that uses incentivisation, recognition and social interaction – all driven by an ...
Anne Lancaster
doaj +1 more source
Reinforced Video Captioning with Entailment Rewards
, 2017 Sequence-to-sequence models have shown promising improvements on the temporal task of video captioning, but they optimize word-level cross-entropy loss during training.
Bansal, Mohit, Pasunuru, Ramakanth
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Beyond Model-Checking CSL for QBDs: Resets, Batches and Rewards [PDF]
, 2005 We propose and discuss a number of extensions to quasi-birth-death models (QBDs) for which CSL model checking is still possible, thus extending our recent work on CSL model checking of QBDs. We then equip the QBDs with rewards, and discuss algorithms and
Haverkort, Boudewijn R., Remke, Anne
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source