Results 11 to 20 of about 22,528 (106)

Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. [PDF]

J Extracell Vesicles, 2023
Abstract Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication and promising biomarkers and therapeutics in the central nervous system (CNS). Human brain‐derived EVs (BDEVs) provide a comprehensive snapshot of physiological changes in the brain's environment, however, the isolation of BDEVs and the comparison of
Zhang Z, Yu K, You Y, Jiang P, Wu Z, DeTure MA, Dickson DW, Ikezu S, Peng J, Ikezu T.   +9 more
europepmc   +2 more sources

Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. METHODS We investigated the association of AD with both common variants and aggregates of rare coding and non‐coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data ...
Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Alzheimer's Disease Sequencing Project, Schellenberg GD, Destefano AL, Haines JL, Peloso GM.   +34 more
europepmc   +2 more sources

Compendium of proteins containing segments that exhibit zero‐tolerance to amino acid variation in humans

Protein Science, Volume 31, Issue 9, September 2022., 2022
Abstract Genetic missense tolerance ratio (MTR) analysis systematically evaluates all possible segments in a given protein‐encoding transcript found in the human population. This method scores each segment for the number of observed missense variants versus the number of silent mutations in that same segment.
Adam L. Sanders, Jake N. Hermanson, David C. Samuels, Lars Plate, Charles R. Sanders   +4 more
wiley   +1 more source

UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease

Advanced Science, Volume 9, Issue 7, March 4, 2022., 2022
Netrin‐1 is reduced in the brains of Parkinson's disease (PD) patients and PD genetic and neurotoxin mouse models, accompanied with prominent asparagine endopeptidase (AEP) activation and UNC5C fragmentation. Netrin‐1 deprivation in primary cultures induces AEP and caspase‐3 activation, triggering UNC5C fragmentation and neuronal loss.
Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye   +6 more
wiley   +1 more source

Parent-reported feeding characteristics in children with ASD vs. children who are typically developing

The Egyptian Journal of Otolaryngology, 2021
Background Parents of children with autism spectrum disorders (ASDs) often report that their children have multiple dietary behavior problems than parents of typically developing (TD) children do.
Nesreen Fathi Mahmoud, Rehab Safwat Abdelhameed, Sherif A. Abdelmonam, Ahmed Ali Abdelmonem, Doaa Mahmoud Khalil, Shimaa Ahmed Saleh Bakia   +5 more
doaj   +1 more source

Efficacy of autologous platelet-rich plasma on graft uptake in myringoplasty: a single-blinded randomized control trial

The Egyptian Journal of Otolaryngology, 2022
Background and aim Chronic otitis media is defined as a chronic inflammation of the middle ear cleft producing irreversible pathological changes. The myringoplasty aims at the reconstruction of the tympanic membrane using a graft material.
R. Vignesh, V. Nirmal Coumare, S. Gopalakrishnan, P. Karthikeyan   +3 more
doaj   +1 more source

Nasopharyngeal Foreign Body with Unusual Presentation [PDF]

Iranian Journal of Otorhinolaryngology
Introduction: An unusual nasopharyngeal foreign body in a very young child with no clinical symptoms is a rare case presentation. Case Report: A nine-month-old child presented with a suspected history of foreign body ingestion without any clue to the ...
Pratik Kumar, Meenakshi Sachdeva, Nandini Shruti   +2 more
doaj   +1 more source

Predictors of central vestibular disorders from videonystagmography tests

The Egyptian Journal of Otolaryngology, 2016
En Abstract Background The diagnosis of central vestibular lesion is challenging and sometimes there is an overlap in symptoms and signs with a peripheral vestibular lesion.
Enass S. Mohamed
doaj   +1 more source

The relationship between the electrical stapedial muscle reflex threshold and electrical and behavioral measures in cochlear implant patients

The Egyptian Journal of Otolaryngology, 2016
Programming of multichannel cochlear implants (CIs) requires subjective responses to a series of sophisticated psychophysical percepts. It is often difficult for young prelinguistically deaf children to provide adequate responses for device fitting. This
Samir Asal, Ossama A. Sobhy, Mohammed Nooman   +2 more
doaj   +1 more source

Ant Colony Optimisation for Backward Production Scheduling

Advances in Artificial Intelligence, Volume 2012, Issue 1, 2012., 2012
The main objective of a production scheduling system is to assign tasks (orders or jobs) to resources and sequence them as efficiently and economically (optimised) as possible. Achieving this goal is a difficult task in complex environment where capacity is usually limited.
Leandro Pereira dos Santos, Guilherme Ernani Vieira, Higor Vinicius dos R. Leite, Maria Teresinha Arns Steiner, Deacha Puangdownreong   +4 more
wiley   +1 more source