Results 11 to 20 of about 41,370 (153)

Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. [PDF]

J Extracell Vesicles, 2023
Abstract Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication and promising biomarkers and therapeutics in the central nervous system (CNS). Human brain‐derived EVs (BDEVs) provide a comprehensive snapshot of physiological changes in the brain's environment, however, the isolation of BDEVs and the comparison of
Zhang Z, Yu K, You Y, Jiang P, Wu Z, DeTure MA, Dickson DW, Ikezu S, Peng J, Ikezu T.   +9 more
europepmc   +2 more sources

Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. METHODS We investigated the association of AD with both common variants and aggregates of rare coding and non‐coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data ...
Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Alzheimer's Disease Sequencing Project, Schellenberg GD, Destefano AL, Haines JL, Peloso GM.   +34 more
europepmc   +2 more sources

Compendium of proteins containing segments that exhibit zero‐tolerance to amino acid variation in humans

Protein Science, Volume 31, Issue 9, September 2022., 2022
Abstract Genetic missense tolerance ratio (MTR) analysis systematically evaluates all possible segments in a given protein‐encoding transcript found in the human population. This method scores each segment for the number of observed missense variants versus the number of silent mutations in that same segment.
Adam L. Sanders, Jake N. Hermanson, David C. Samuels, Lars Plate, Charles R. Sanders   +4 more
wiley   +1 more source

UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease

Advanced Science, Volume 9, Issue 7, March 4, 2022., 2022
Netrin‐1 is reduced in the brains of Parkinson's disease (PD) patients and PD genetic and neurotoxin mouse models, accompanied with prominent asparagine endopeptidase (AEP) activation and UNC5C fragmentation. Netrin‐1 deprivation in primary cultures induces AEP and caspase‐3 activation, triggering UNC5C fragmentation and neuronal loss.
Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye   +6 more
wiley   +1 more source

Feeding and Draining Vessel Ligation with Sclerotherapy of High Flow Arteriovenous Malformations in the Head and Neck

Philippine Journal of Otolaryngology Head and Neck Surgery, 2014
High flow arteriovenous malformations (AVMs) are infiltrative, invading tissue planes and structures and may be life threatening when they bleed.1 They have a feeding artery and an anomalous capillary bed shunting blood from the arterial system to the ...
Felixberto D. Ayahao
doaj   +1 more source

Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1

Nature Communications, 2018
During translation termination in bacteria, the release factors RF1 and RF2 are recycled from the ribosome by RF3. While high-resolution structures of the individual termination factors on the ribosome exist, direct structural insight into how RF3 ...
M. Graf, P. Huter, C. Maracci, M. Peterek, M. Rodnina, Daniel N. Wilson   +5 more
semanticscholar   +1 more source

Development and Validation of Markers for the Fertility Restorer Gene Rf1 in Sunflower

International Journal of Molecular Sciences, 2019
Hybrid breeding in sunflowers based on CMS PET1 requires development of restorer lines carrying, in most cases, the restorer gene Rf1. Markers for marker-assisted selection have been developed, but there is still need for closer, more versatile, and co ...
R. Horn, Aleksandra Radanović, Lena Fuhrmann, Yves Sprycha, S. Hamrit, M. Jocković, D. Miladinović, C. Jansen   +7 more
semanticscholar   +1 more source

Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation*

Journal of Biological Chemistry, 2017
Selenoproteins contain the amino acid selenocysteine (Sec), co-translationally inserted at a predefined UGA opal codon by means of Sec-specific translation machineries.
Q. Cheng, Elias S. J. Arnér
semanticscholar   +1 more source

Bleeding Time using Moringa oleifera (Malunggay) Leaf Extract versus Saline Control in a Rabbit Epistaxis Model: A Randomized Controlled Trial

Philippine Journal of Otolaryngology Head and Neck Surgery, 2017
Objective: To determine bleeding time using Moringa oleifera leaf extract versus saline control in an experimental epistaxis model. Methods:             Design:           Randomized controlled trial             Setting:           Tertiary ...
Paula Luz G. Caballero, Joseph E. Cachuela   +1 more
doaj   +1 more source

Laryngeal Cancer Neck Node Metastases: Patterns of Spread

Philippine Journal of Otolaryngology Head and Neck Surgery, 2017
Objective: To determine the patterns of neck node metastases of patients with laryngeal carcinoma in our institution. Methods:             Design:           Chart Review             Setting:           Tertiary Public Hospital Subjects:       
Mark Jansen D.G. Austria, Rodante A. Roldan   +1 more
doaj   +1 more source