Visual and Ocular Manifestations of Alzheimer's Disease and Their Use as Biomarkers for Diagnosis and Progression [PDF]
, 2016 Alzheimer's disease (AD) is the most common form of dementia affecting the growing aging population today, with prevalence expected to rise over the next 35 years.
Brenton, J +3 more
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Stem Cells International, Volume 2019, Issue 1, 2019., 2019 Glaucoma is characterized by progressive, irreversible damage to the retinal ganglion cells (RGCs) and their axons. Our previous study has shown that the intravitreal transplantation of human umbilical cord mesenchymal stem cells (hUC‐MSCs) reveals a neuroprotective role in microsphere injection‐induced ocular hypertension (OHT) rat models.
Shangli Ji +4 more
wiley +1 more source
Dose-ranging and further therapeutic evaluation of a bicistronic humanized TrkB-BDNF gene therapy for glaucoma in rodents. [PDF]
Mol Neurodegener AdvBackground: Glaucoma is a leading cause of irreversible blindness, characterized by the progressive degeneration of retinal ganglion cells (RGCs). Activation of the Tropomyosin receptor kinase B (TrkB) pathway by mature brain-derived neurotrophic factor (
Osborne A +13 more
europepmc +7 more sources
The rotterdam study: 2014 objectives and design update [PDF]
, 2013 The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory ...
Darwish Murad, S. (Sarwa) +12 more
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Zhongguo cuzhong zazhi目的 探讨外侧膝状体及其后中枢视觉通路受损继发逆行跨突触变性视神经病变（transsynaptic retrograde degeneration of optic neuropathy，TRDON）患者的临床特征，观察视网膜神经纤维层（retinal nerve fiber layer，RNFL）、视网膜神经节细胞层（retinal ganglion cell layer，RGCL）厚度的变化。 方法 本研究为回顾性临床研究。收集2022年9月—2023年9月就诊于西安市第一医院神经内科和神经眼科，
霍燕，蔺雪梅，刘仲仲，饶兰平，宋沉生，刘佩，逯青丽，王静，吴松笛
doaj +1 more source
El papel de la mitofagia en la neurogénesis y la neurodegeneración [PDF]
, 2023 Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, leída el 13-07-2022The vertebrate neural retina is a structure made up of six neuronal and one glial cell type, which arise from a pool of multipotent progenitor cells.
Teresak, Petra
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Neurodegeneration of the retina in mouse models of Alzheimer’s disease: what can we learn from the retina? [PDF]
, 2011 Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disease commonly found among elderly. In addition to cognitive and behavioral deficits, vision abnormalities are prevalent in AD patients.
A Gruart +117 more
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Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline [PDF]
, 2020 Background: Alzheimer's disease (AD) pathology precedes symptoms and its detection can identify at-risk individuals who may benefit from early treatment.
A.A. Sadun A A +15 more
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Influence of coherence length, signal-to-noise ratio, log transform, and low-pass filtering on layer thickness assessment with OCT in the retina [PDF]
, 2016 Optical coherence tomography (OCT) images of the retina are inevitably affected by the finite width of the coherence function and noise. To make low-reflective layers visible, the raw OCT signal is log transformed; to reduce the effect of noise the ...
Cense, Barry +3 more
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Development of Techniques for Analysis of the Human Retinal Ganglion Cell Transcriptome: Application to the Role of Calcium in RGC Death in Glaucoma [PDF]
, 2013 Purpose: Irreversible retinal ganglion cell (RGC) death is the reason for visual loss in glaucoma. However, the mechanisms of RGC death remain unclear.
Ma, Ning
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