Results 191 to 200 of about 29,693 (245)

CDK7 as a Potential Exploratory Biomarker for Distinguishing Acute Myocardial Infarction Subtypes via DDR Pathways: Evidence From a Bangladeshi Cohort

Clinical Cardiology, Volume 49, Issue 6, June 2026.
Differential expression of DNA damage response genes was evaluated in Bangladeshi AMI patients. CDK7 showed significantly higher expression in NSTEMI compared to STEMI, while ATM, OGG1, and NBN showed no subtype‐specific differences, highlighting potential transcriptional heterogeneity between AMI subtypes.
Rifat Hossain Ripon, Hasnat Zahin, Abdullah Al Noman, Abdullah Al Saba, Mohammad Sayem, A.H.M. Nurun Nabi, Tahirah Yasmin   +6 more
wiley   +1 more source

Wearable PPG Multi-Sensor for Skin Humidity, Temperature, and Contact Pressure Measurement in Weak Magnetic Field Environment: First-Step Experiments. [PDF]

Bioengineering (Basel)
Přibil J, Přibilová A, Dermek T.
europepmc   +1 more source

First‐line envafolimab plus recombinant human‐endostatin in advanced non–small cell lung cancer with PD‐L1 tumor proportion score ≥1% (Endouble): A multicenter, prospective, single‐arm, phase 2 trial

Cancer, Volume 132, Issue 11, 1 June 2026.
Envafolimab combined with recombinant human endostatin demonstrates favorable efficacy and tolerable toxicity in non–small cell lung cancer patients. MMP1 and TNFRSF6B may be predictive biomarkers for treatment response. Abstract Background This trial evaluates the efficacy and safety of combining envafolimab and recombinant human endostatin (Rh ...
Changhong Dong, Liang Liu, Yun Qiao, Mei Wang, Daan Song, Lihua Zhou, Yajun Ji, Yan Li, Fendou Ding, Hao Wang, Min Zhuang, Lei Wang, Zhenghong Liu, Haitao Fei, Xiangjun Guo, Baoxiang Bian, Chunluan Yuan, Guanghui Xu, Lijian Fang, Yan Li, Ziyan Song, Kaiyuan Hui, Xiaodong Jiang   +22 more
wiley   +1 more source

Endoscopic Lung Volume Reduction with Valves Improves Cardiovascular Adaptability and 6-MWT Performance in Severely Limited COPD Patients. [PDF]

Int J Chron Obstruct Pulmon Dis
Farber L, Pappe E, Sgarbossa T, Neumann K, Witzenrath M, Hübner RH, Saccomanno J.   +6 more
europepmc   +1 more source

MiR‐21‐5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
miR‐21‐5p protects embryonic growth and heart function during developmental hypoxia by dampening HIF responses and shifting gene networks toward improved cardiomyocyte survival and calcium handling. This work identifies miR‐21‐5p as a promising therapeutic target for preventing fetal growth restriction and cardiovascular impairment in high‐risk ...
Bernardo J. Krause, Ximena Calle, Ranya V. Kumar, Youguo Niu, Oriana Ramirez‐Herrera, Damariz Gonzalez, Barbara Bernal, Sage G. Ford, Rachael C. Crew, Anna L. K. Cochrane, German A. Arenas, Alex Di Genova, Dino A. Giussani   +12 more
wiley   +1 more source

Evaluation of Chitosan-Pimelate Buccal Film Loaded with Duloxetine-Modified Sage Lipid Carriers Nanoformulation for Effective Antidepressant Activity in a Rat Model. [PDF]

Int J Nanomedicine
El-Dakroury WA, Nomier YA, Said AR, Taura MG, Soliman Doghish A, Shalaby A, Sarhan OM.   +6 more
europepmc   +1 more source

Evaluating Anesthetics for Improving Scientific Research and Welfare Using Larval Zebrafish

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Using physiological and behavioral assays, we quantified the effectiveness and appropriateness of six commonly used fish anesthetics on zebrafish embryos. Different anesthetics performed better under different contexts. Figure prepared using BioRender.com.
Sylvia Dimitriadou, Mhairi Miller, Ali Pilehvar, Lynne U. Sneddon, Jessica L. Bamsey, Damilola Hogan‐Bassey, Maciej Trznadel, Jonathan S. Ball, Aya Takesono, Courtney Hillman, Hannah Rickard, Grace Popplewell, Jenna Corcoran, Tetsuhiro Kudoh, Charles R. Tyler, Matthew J. Winter   +15 more
wiley   +1 more source

Lateral flow-based assay for simple and rapid visual detection of Asian-type DEL. [PDF]

PeerJ
Bunpoom Y, Leelayuwat C, Tippayawat P, Wongwattanakul M, Simtong P.   +4 more
europepmc   +1 more source

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1650-1661, June 2026.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Physiological, morphological hair, and blood parameters of the goat group genetic Azul in the semiarid. [PDF]

Int J Biometeorol
Miranda JR, Costa RG, Ribeiro MN, Saraiva EP, da Silva VC, Ribeiro NL.   +5 more
europepmc   +1 more source