Results 81 to 90 of about 16,904 (234)

Evolutionary genetics of the human Rh blood group system

Human Genetics, 2012
G. Perry, Yali Xue, Richard S. Smith, Wynn K. Meyer, Minal Çalışkan, Omar Yanez-Cuna, Arthur S. Lee, M. Gutierrez-Arcelus, C. Ober, E. Hollox, C. Tyler-Smith, Charles Lee   +11 more
semanticscholar   +1 more source

CCR5 predicts neurotoxicity in CAR‐T‐cell therapy

British Journal of Haematology, EarlyView.
Patients undergoing chimeric antigen receptor T (CAR T)‐cell therapy are at risk of developing immune effector cell‐associated neurotoxicity syndrome (ICANS). We observed an upregulation of CCR5 and CCR2 expression in CD4+ T cells among patients who developed ICANS.
Ayal Rozenberg, Shahar Shelly, Raz Winer, Riva Fineman, Shani Haller, Shimrit Ringelstein‐Harlev, Israel Henig, Dana Yehudai‐Ofir, Tsila Zuckerman, Tamar Tadmor, Reut Harel, Esther Ganelin‐Cohen, Ofrat Beyar‐Katz   +12 more
wiley   +1 more source

Laboratory assessment of fetomaternal haemorrhage and Rh immune globulin management: Canadian practice and scoping review

British Journal of Haematology, EarlyView.
Fetomaternal haemorrhage (FMH) in RhD‐negative individuals can cause alloimmunization with future antibody‐mediated destruction of fetal red blood cells. Accurate FMH estimation guides Rh immune globulin dosing. The rosette test, the most used qualitative method, may yield false negatives with fetal RhD variants or false positives with maternal ...
Omar I. Hajjaj, Jeannie Callum, Nadine Shehata, Ashley Farrell, Gwen Clarke, Lani Lieberman   +5 more
wiley   +1 more source

Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis

Contact Dermatitis, EarlyView.
ABSTRACT Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should ...
Meital Portugal‐Cohen, Warangkana Lohcharoenkal, Evelyn Kelemen, Inge Kortekaas Krohn, Shauni De Vriese, Danuta Gutowska‐Owsiak, Ivone Jakasa, Dijana Furundžić, Anna Zalewska‐Janowska, Sandrine Dubrac   +9 more
wiley   +1 more source

Synovial fluid alpha‐2‐macroglobulin, gelsolin and lubricin distinguish between osteoarthritic and healthy equine joints

Equine Veterinary Journal, EarlyView.
Abstract Background Synovial fluid (SF) is an ideal sentinel fluid for osteoarthritis (OA) diagnosis and prognostication due to its critical homeostatic role, proximity to articular tissues and immune cell composition. Untargeted proteomics enable identification of soluble markers for diagnostic and therapeutic applications while minimising bias ...
Erica J. Secor, Sydney J. Womack, Machiel P. Ysebaert, Marshall J. Colville, Heidi L. Reesink   +4 more
wiley   +1 more source

Impact of N‐linked glycans on the dual short fibulin/LTBP‐4 axes regulating elastogenesis

The FEBS Journal, EarlyView.
Elastic fiber assembly is orchestrated by multiple glycoproteins. We delineate the molecular basis of two key axes involved in elastic fiber formation—LTBP‐4L/fibulin‐4 and LTBP‐4S/fibulin‐5. We show that N‐linked glycans on these glycoproteins regulate their interactions and conformations, both of which are critical aspects in elastic fiber formation.
Valentin Nelea, Heena Kumra, Chae Syng Lee, Daniel Williamson, Hana Hakami, Rong‐Mo Zhang, Neha E. H. Dinesh, Robert Haltiwanger, Dieter P. Reinhardt   +8 more
wiley   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source

Variation in clinical presentation, complications and outcomes for Māori and Pacific peoples among hospitalised adults with COVID‐19 in 2022, Aotearoa New Zealand

Internal Medicine Journal, EarlyView.
Abstract Background Pacific region‐specific data on the clinical course of COVID‐19 are limited. We aimed to describe clinical features and outcomes from Aotearoa New Zealand patients, focusing on Māori and Pacific peoples. Methods We conducted a retrospective cohort study among adults (≥16 years) hospitalised due to COVID‐19 at 11 hospitals from ...
Michael J. Maze, Haylea Rodgers, Jonathan Williman, Rebekah Anstey, Emma Best, Hasan Bhally, Aliya Bryce, Catherina Chang, Kevin Chen, Jack Dummer, Michael Epton, William Good, Jennifer Goodson, Corina Grey, Kate Grimwade, Robert J. Hancox, Redzuan Hassan, Thomas Hills, Sandra Hotu, Colin McArthur, Susan Morpeth, David R. Murdoch, Fiona Pease, Romana Pylypchuk, Nigel Raymond, Stephen Ritchie, Deborah Ryan, Vanessa Selak, Malina Storer, Tony Walls, Rachel Webb, Conroy Wong, Karen Wright   +32 more
wiley   +1 more source

Coordinating a bi‐level blood supply chain with interactions between supply‐side and demand‐side operational decisions

International Transactions in Operational Research, EarlyView.
Abstract In most blood supply chains, blood centers and hospitals make individual decisions, resulting in an inefficient structure of the blood supply chain, which in turn renders supply and demand matching a challenging exercise. In this work, we make the very first attempt to optimize the interaction between blood centers and hospitals.
Mohammad S. Moshtagh, Yun Zhou, Manish Verma   +2 more
wiley   +1 more source

Towards an Integrated Person‐Centred Care Pathway to Support the Recovery Journey Post Hip Fracture: A Qualitative Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore the pathway of care for people post hip fracture and define what is important for person‐centred recovery. Design Qualitative design using interpretive descriptive methodology, guided by the Health Empowerment theoretical framework.
Sharon Allsop, Helen Rawson, Julia Morphet   +2 more
wiley   +1 more source