Results 41 to 50 of about 99,358 (330)

Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy. [PDF]

PLoS ONE, 2017
Interleukins-6 (IL-6)/GP130 signaling pathway represents a promising target for cancer therapy due to its critical role in survival and progression of multiple types of cancer.
Hui Xiao, Hemant Kumar Bid, Xiang Chen, Xiaojuan Wu, Jia Wei, Yang Bian, Chengguang Zhao, Huameng Li, Chenglong Li, Jiayuh Lin   +9 more
doaj   +1 more source

A RARE CASE REPORT OF PARATESTICULAR RHABDOMYOSARCOMA IN AN ADULT PATIENT

Pakistan Armed Forces Medical Journal, 2021
Rhabdomyosarcoma is a malignancy of mesenchymal tissue origin typically occurring in childhood and adolescence, with an incidence rate of of 4.3 patients per million population per anum. Primary rhabdomyosarcoma of para-testicular origin is an infrequent
Mussadique Ali, Chandumal ., Manzoor Khan, Jhanzeb Iftikhar, Samia Yasmeen, Umm e Kalsoom Awan   +5 more
doaj   +1 more source

Long-term renal function and hypertension in adult survivors of childhood sarcoma [PDF]

, 2018
Aim: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for ...
Andreoli, Gianmarco, Bonci, Enea, Celani, Camilla, Marrucci, Oriana, Pedetti, Valeria, Schiavetti, Amalia, Varrasso, Giulia   +6 more
core   +1 more source

Insurance impacts survival for children, adolescents, and young adults with bone and soft tissue sarcomas. [PDF]

, 2020
BackgroundWhile racial/ethnic survival disparities have been described in pediatric oncology, the impact of income has not been extensively explored. We analyzed how public insurance influences 5-year overall survival (OS) in young patients with sarcomas.
Goldsby, Robert E, Murphy, Patricia, Penumarthy, Neela L, Shiboski, Stephen C, Winestone, Lena E, Wustrack, Rosanna   +5 more
core   +1 more source

Orbital Rhabdomyosarcoma [PDF]

Cancer Control, 2004
Although rhabdomyosarcoma (RMS) is a rare tumor among the entire group of mesenchymal malignancies, it is a relatively common lesion and significant challenge for the ocular oncologist in terms of its diagnosis and management.A comprehensive literature search of articles published over the past 30 years in PubMed was conducted.Orbital RMS usually ...
Karcioglu, Zeynel A., Hadjistilianou, D, Rozans, Marta, Defrancesco, Sonia   +3 more
openaire   +4 more sources

Head and neck rhabdomyosarcoma with TFCP2 fusions and ALK overexpression: a clinicopathological and molecular analysis of 11 cases

Histopathology, 2020
Primary intraosseous rhabdomyosarcoma (RMS) is a rare entity defined by EWSR1/FUS–TFCP2 or, less commonly, MEIS1–NCOA2 fusions. The lesions often show a hybrid spindle and epithelioid phenotype, frequently coexpress myogenic markers, ALK, and cytokeratin,
Bin Xu, A. Suurmeijer, Narasimhan P. Agaram, Lei Zhang, C. Antonescu   +4 more
semanticscholar   +1 more source

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

BMC Cancer, 2019
Background Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere with rhabdomyosarcoma growth, no ...
Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini, Pier-Luigi Lollini   +7 more
doaj   +1 more source

Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma

Nature Genetics, 2019
Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers (SEs) to activate transcription of cell-identity specifying gene networks, and are critical in promoting cancer.
B. Gryder, S. Pomella, C. Sayers, Xiaoli S. Wu, Y. Song, Anna M. Chiarella, Sukriti Bagchi, Hsien-Chao Chou, Ranu S. Sinniah, Ashley Walton, Xinyu Wen, R. Rota, Nathaniel A. Hathaway, K. Zhao, Jiji Chen, C. Vakoc, J. Shern, Benjamin Z. Stanton, J. Khan   +18 more
semanticscholar   +1 more source

Recent Advances and Challenges in the Treatment of Rhabdomyosarcoma

Cancers, 2020
Rhabdomyosarcoma, the most common soft tissue sarcoma noted in childhood, requires multimodality treatment, including chemotherapy, surgical resection, and/or radiation therapy.
S. Miwa, N. Yamamoto, K. Hayashi, A. Takeuchi, K. Igarashi, H. Tsuchiya   +5 more
semanticscholar   +1 more source

Breast metastasis in an adult woman with alveolar rhabdomyosarcoma of the ethmoid sinus

Radiology Case Reports, 2014
A new breast mass was identified in an adult woman undergoing treatment for a known ethmoid sinus alveolar rhabdomyosarcoma. Histopathological evaluation revealed alveolar rhabdomyosarcoma metastatic to the breast.
Sean D. Raj, MD, Karuna M. Raj, MD, Savitri Krishnamurthy, MD, Ashrita Brahmaroutu, Gary J. Whitman, MD   +4 more
doaj   +1 more source