Results 51 to 60 of about 54,150 (267)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

An Unusual Imaging Finding of Breast Metastasis from Rhabdomyosarcoma

대한영상의학회지, 2017
Rhabdomyosarcoma mainly occurs in the pediatric age group, with the primary tumor originating from the trunk, neck, and extremities. Metastasis of rhabdomyosarcoma to the breast is very rare.
Youngsun Ko, Jee Eun Lee, Jin Chung, Jeoung Hyun Kim, In Hye Chae, Eun Suk Cha   +5 more
doaj   +1 more source

Perianal-Perineal Localized Alveolar-Embryonal (Mixed) Type Rhabdomyosarcoma: Rare Localization, Case Report [PDF]

, 2017
A 17-year old girl who had been admitted to another hospital with perianal swelling and pain was diagnosed with perianal abscess. She had been given anti-biotheraphy and anti-inflamatory medication.
Hakan Maral, Mustafa Gök, Yasemin Durum, Canten Tataroğlu   +3 more
core   +1 more source

Embryonal Rhabdomyosarcoma of the Tongue in Adults

, 2023
(1) Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the first two decades of life. One third of cases appear in the head and neck, with 60% of these being embryonal type. RMS is extremely rare in adults, comprising only 1% of
Carlos Navarro Cuéllar, Nuria Bonsfills, Manuel Tousidonis Rial, José Ignacio Salmerón, Antúnez Conde, Raúl, Pujol, Carolina Agra, Díez Montiel, Alberto, Raúl Antúnez-Conde, Carolina Agra Pujol, Ochandiano, Santiago, Antúnez-Conde, Raúl, Francisco Alijo Serrano, Tousidonis Rial, Manuel, Salmerón, José Ignacio, Bonsfils, Nuria, Bonsfills, Nuria, Santiago Ochandiano, Navarro Cuéllar, Carlos, Agra Pujol, Carolina, Salmerón Escobar, José Ignacio, Ochandiano Caicoya, Santiago, Serrano, Francisco Alijo, Alijo Serrano, Francisco, Díez-Montiel, Alberto, Alberto Díez-Montiel   +24 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Myodifferentiation of Rhabdomyosarcoma [PDF]

, 2022
Rhabdomyosarcoma is an aggressive pediatric soft tissue malignancy thought to originate from muscle progenitor cells that failed to reach terminal differentiation.
Sroka, Martyna W
core  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Clinical and Molecular Characterization of 46 Patients With Beckwith–Wiedemann Spectrum and Uniparental Disomy of 11p15

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Beckwith–Wiedemann spectrum (BWSp) is an overgrowth disorder characterized by its main clinical features macrosomia, macroglossia, and abdominal wall defects. BWSp is caused by (epi)genetic chromosome 11p15 alterations with approximately 20%–27% of patients exhibiting mosaic paternal uniparental disomy of chromosome 11p15 (pUPD11p15).
Saskia M. Maas, Peter Lauffer, Niels Vos, Paola Lombardi, Marcel M. A. M. Mannens, Youp Zegers, Laura J. C. M. van Zutven, Aeilko H. S. Zwinderman, Mieke M. van Haelst, Jet Bliek   +9 more
wiley   +1 more source

Paediatric Para-Meningeal Alveolar Rhabdomyosarcoma in the Nasal Cavity

Bengal Journal of Otolaryngology and Head Neck Surgery
Introduction Rhabdomyosarcoma is the second most common malignant soft tissue tumor, which is of skeletal muscle in origin. Alveolar subtype of rhabdomyosarcoma is commonly seen in 10-25 years of age. We present a rare case of alveolar rhabdomyosarcoma
Cindya Vidyadharan, Aju Ravindran, Divya Bharathan   +2 more
doaj   +1 more source

Persistent pleural effusion in an infant with an unusual diagnosis: congenital alveolar rhabdomyosarcoma

, 2020
Rhabdomyosarcoma (RMS) is a malignant form of neoplasm that originates from skeletal muscle. RMSs can exist anywhere in the human body but are more commonly detected in the neck region and extremities. The alveolar type is one of the subtypes of RMS that
Ismail Yurtsever, Damat Baghishov, Can Yozgat, Sahande Elagoz, Yilmaz Yozgat, Osman Cemil Akdemir, Nigar Bayramova, Fatma Betul Cakir, Osman Yesilbas, Nur Tekin   +9 more
core   +1 more source