Results 21 to 30 of about 158,952 (268)

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Middle East Respiratory Syndrome, caused by the MERS coronavirus (MERS-CoV), continues to cause severe respiratory disease with a high case fatality rate.
E. de Wit, F. Feldmann, Jacqueline Cronin, R. Jordan, A. Okumura, T. Thomas, D. Scott, T. Cihlář, H. Feldmann   +8 more
semanticscholar   +1 more source

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

Science, 2020
Immunity from reinfection One of the many open questions about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is whether an individual who has cleared the virus can be infected a second time and get sick. Chandrashekar et al.
A. Chandrashekar, Jinyan Liu, Amanda J. Martinot, K. McMahan, N. Mercado, Lauren Peter, Lisa H. Tostanoski, Jingyou Yu, Z. Maliga, M. Nekorchuk, K. Busman-Sahay, Margaret Terry, Linda M. Wrijil, Sarah Ducat, David R. Martinez, C. Atyeo, S. Fischinger, J. Burke, Matthew D. Slein, Laurent Pessaint, Alex Van Ry, J. Greenhouse, Tammy Taylor, Kelvin Blade, Anthony Cook, Brad Finneyfrock, Renita Brown, Elyse Teow, Jason Velasco, R. Zahn, F. Wegmann, P. Abbink, E. Bondzie, Gabriel Dagotto, M. Gebre, Xuan He, C. Jacob-Dolan, N. Kordana, Zhenfeng Li, M. Lifton, S. Mahrokhian, Lori F. Maxfield, Ramya Nityanandam, Joseph P. Nkolola, A. Schmidt, Andrew D. Miller, R. Baric, G. Alter, P. Sorger, J. Estes, H. Andersen, M. Lewis, D. Barouch   +52 more
semanticscholar   +1 more source

Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

Nature Communications, 2021
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to assess the safety ...
F. J. Salguero, A. White, Gillian S. Slack, S. Fotheringham, Kevin R. Bewley, K. Gooch, S. Longet, H. Humphries, R. Watson, Laura Hunter, K. Ryan, Y. Hall, L. Sibley, C. Sarfas, Lauren Allen, Marilyn Aram, Emily Brunt, Phillip J. Brown, K. Buttigieg, Breeze E. Cavell, R. Cobb, N. Coombes, A. Darby, O. Daykin-Pont, Mike Elmore, Isabel García-Dorival, Konstantinos Gkolfinos, K. Godwin, Jade Gouriet, R. Halkerston, D. Harris, T. Hender, Catherine M. K. Ho, C. Kennard, Daniel Knott, Stephanie Leung, Vanessa Lucas, Adam Mabbutt, Alexandra L. Morrison, Charlotte Nelson, D. Ngabo, Jemma Paterson, E. Penn, S. Pullan, Irene Taylor, T. Tipton, Stephen R. Thomas, J. Tree, C. Turner, Edith E. Vamos, Nadina I. Wand, Nathan R. Wiblin, S. Charlton, Xiao-Jie Dong, B. Hallis, G. Pearson, E. Rayner, Andrew G. Nicholson, S. Funnell, J. Hiscox, Mike Dennis, F. Gleeson, Sally Sharpe, Miles W. Carroll   +63 more
semanticscholar   +1 more source

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

Nature, 2020
Effective therapies to treat coronavirus disease 2019 (COVID-19) are urgently needed. While many investigational, approved, and repurposed drugs have been suggested as potential treatments, preclinical data from animal models can guide the search for ...
Brandi N. Williamson, F. Feldmann, Benjamin Schwarz, Kimberly Meade-White, D. Porter, Jonathan E. Schulz, Neeltje van Doremalen, I. Leighton, C. Yinda, L. Pérez-Pérez, A. Okumura, J. Lovaglio, P. Hanley, G. Saturday, C. Bosio, S. Anzick, Kent D. Barbian, T. Cihlář, C. Martens, D. Scott, V. Munster, E. de Wit   +21 more
semanticscholar   +1 more source

Relationship between the ABO blood group and lung cancer susceptibility

Medical Journal of Babylon, 2021
Background: Lung cancer (LC) is one of the well-known fatal malignant neoplasms worldwide. Objective: The objective of this study was to determine the potential relationship between ABO and Rhesus blood groups with LC.
Zahir Salih Hussein
doaj   +1 more source

Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

Nature, 2020
An outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started in Wuhan (China) in December 20191,2.
V. Munster, F. Feldmann, Brandi N. Williamson, Neeltje van Doremalen, L. Pérez-Pérez, Jonathan E. Schulz, Kimberly Meade-White, A. Okumura, Julie A. Callison, Beniah Brumbaugh, V. Avanzato, Rebecca Rosenke, P. Hanley, G. Saturday, D. Scott, E. Fischer, E. de Wit   +16 more
semanticscholar   +1 more source

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

Science, 2020
A beneficial cocktail Since the start of the coronavirus disease 2019 (COVID-19) pandemic, considerable effort has gone into generating and characterizing neutralizing antibodies that could be used as therapeutics.
A. Baum, D. Ajithdoss, R. Copin, A. Zhou, Kathryn Lanza, Nicole Negron, M. Ni, Yi Wei, K. Mohammadi, B. Musser, G. Atwal, A. Oyejide, Yenny Goez-Gazi, John W Dutton, E. Clemmons, Hilary M Staples, Carmen Bartley, Benjamin Klaffke, Kendra J Alfson, M. Gazi, O. Gonzalez, E. Dick, R. Carrion, Laurent Pessaint, Maciel Porto, Anthony Cook, Renita Brown, Vaneesha Ali, J. Greenhouse, Tammy Taylor, H. Andersen, M. Lewis, N. Stahl, A. Murphy, G. Yancopoulos, C. Kyratsous   +35 more
semanticscholar   +1 more source

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

Science, 2020
Immunity from reinfection One of the many open questions about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is whether an individual who has cleared the virus can be infected a second time and get sick. Chandrashekar et al.
Wei Deng, L. Bao, Jiangning Liu, C. Xiao, Jiayi Liu, Jing Xue, Qi Lv, Feifei Qi, Hong Gao, Pin Yu, Yanfeng Xu, Yajin Qu, Feng-di Li, Zhiguang Xiang, Haisheng Yu, Shuran Gong, Mingya Liu, Guanpeng Wang, Shunyi Wang, Zhiqi Song, Ying Liu, Wenjie Zhao, Yunlin Han, Linna Zhao, Xing Liu, Q. Wei, C. Qin   +26 more
semanticscholar   +1 more source

Prevalance of ABO and Rhesus Blood Groups in Blood Donors: A Study from a Tertiary Care Teaching Hospital of Kumaon Region of Uttarakhand [PDF]

Journal of Clinical and Diagnostic Research, 2014
Backround: ABO and Rhesus (Rh) blood group antigens are hereditary characters and are useful in population genetic studies, in resolving medico-legal issues and more importantly for the immunologic safety of blood during transfusion. Aims: This study
Parul Garg, Saloni Upadhyay, Sanjay Singh Chufal, Yuman Hasan, Ishwer Tayal   +4 more
doaj   +1 more source

The natural history of model organisms: the rhesus macaque as a success story of the Anthropocene.

eLife, 2022
Of all the non-human primate species studied by researchers, the rhesus macaque (Macaca mulatta) is likely the most widely used across biological disciplines.
Eve B. Cooper, L. Brent, N. Snyder‐Mackler, Mewa Singh, Asmita Sengupta, S. Khatiwada, S. Malaivijitnond, Zhou Qi Hai, J. Higham   +8 more
semanticscholar   +1 more source