Results 31 to 40 of about 213,696 (264)

Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics

Viruses, 2020
Recent Ebola virus (EBOV) outbreaks in West Africa and the Democratic Republic of the Congo have highlighted the urgent need for approval of medical countermeasures for treatment and prevention of EBOV disease (EVD).
Travis Warren, Elizabeth Zumbrun, Jessica M. Weidner, Laura Gomba, Franco Rossi, Roy Bannister, Jacqueline Tarrant, Matthew Reed, Eric Lee, Jo Lynne Raymond, Jay Wells, Joshua Shamblin, Kelly Wetzel, Ginger Donnelly, Sean Van Tongeren, Nicole Lackemeyer, Jesse Steffens, Adrienne Kimmel, Carly Garvey, Holly Bloomfield, Christiana Blair, Bali Singh, Sina Bavari, Tomas Cihlar, Danielle Porter   +24 more
doaj   +1 more source

Rapid Evolution of BRCA1 and BRCA2 in Humans and Other Primates [PDF]

, 2014
The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA.
Demogines, Ann M., Le, Uyen Q., Lou, Dianne I., McBee, Ross M., Sawyer, Sara L., Stone, Anne C., Wilkerson, Gregory K.   +6 more
core   +3 more sources

Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA

Molecular Therapy: Nucleic Acids, 2015
One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump.
Richard Grondin, Pei Ge, Qingmin Chen, Jessica E Sutherland, Zhiming Zhang, Don M Gash, David K Stiles, Gregory R Stewart, Dinah W Y Sah, William F Kaemmerer   +9 more
doaj   +1 more source

B-Virus and Free-Ranging Macaques, Puerto Rico

Emerging Infectious Diseases, 2004
In Puerto Rico, risk for transmission of B-virus from free-ranging rhesus monkeys to humans has become a serious challenge. An incident with an injured rhesus monkey, seropositive for B-virus, resulted in inappropriate administration of antiviral ...
Kristen Jensen, Francisco Alvarado-Ramy, Janis González-Martínez, Edmundo Kraiselburd, Johnny Rullán   +4 more
doaj   +1 more source

Relationship between the ABO/Rh Blood Group Factors with Coronavirus Disease 2019 Severity and Mortality among Hospitalized Patients in Algeria: A Single-center Study

Journal of Advanced Lung Health
Introduction: The novel coronavirus causes the deadly disease, severe acute respiratory syndrome (SARS). Therefore, it is necessary to identify prognostic factors for patients hospitalized with SARS-coronavirus-2 infection to identify patients with ...
Abdelbassat Ketfi, Karima Zouai, Yacine Djagheri, Kamel Djenouhat, Rama Touahri   +4 more
doaj   +1 more source

Conformation of HIV-1 Envelope Governs Rhesus CD4 Usage and Simian-Human Immunodeficiency Virus Replication

mBio, 2022
Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is the preferred model system for vaccine development because SHIVs encode human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Envs)—a key target of HIV-1 ...
Geraldine Vilmen, Anna C. Smith, Hector Cervera Benet, Rajni Kant Shukla, Ross C. Larue, Alon Herschhorn, Amit Sharma   +6 more
doaj   +1 more source

Melt Electrowriting High Resolution Poly(ethylene‐co‐vinyl acetate) Scaffolds for Soft Tissue Engineering

Advanced Healthcare Materials, EarlyView.
This work pioneers melt electrowriting (MEW) of polyethylene vinyl acetate (PEVA) to fabricate ultra‐compliant, high‐resolution scaffolds. By integrating microscale precision with soft tissue‐like biomechanics, PEVA overcomes stiffness‐driven limitations of conventional MEW polymers, establishing a mechanically biomimetic platform for soft tissue ...
Finn Snow, Darcy De Rauch, Lilith Mabel Caballero Aguilar, Darcy Millett, Jasley Wilding McBride, David R Nisbet, Magdalena Kita, Elena Pirogova, Robert Michail Ivan Kapsa, Anita Quigley   +9 more
wiley   +1 more source

The relationship between ABO/rhesus blood groups and type 2 diabetes mellitus in Maghnia, western Algeria

South African Family Practice, 2011
Background: To determine the relationship between ABO/rhesus (Rh) blood groups and type 2 diabetes mellitus in a western Algerian population. Method: This case-control study was conducted at the Regional Hospital Centre of Maghnia, Tlemcen, from July ...
M. Dali Sahi, A. Aour Metri, F. Belmokhtar, R. Belmokhtar, F. Bouazza   +4 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Successful Management of Hemolytic Anemia Due to Rh-immunization, Diagnosed Antenatally

Caucasian Medical Journal
Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in maternal-fetal medicine, despite advancements in prevention and management.
Sevinch Mahmudova, Gulnar Elizade, Nezrin Hesenli, Turab Janbakhishov, Sarkhan Elbayiyev   +4 more
doaj   +1 more source