Results 51 to 60 of about 158,952 (268)

Heterozygote Advantage Probably Maintains Rhesus Factor Blood Group Polymorphism: Ecological Regression Study. [PDF]

PLoS ONE, 2016
Rhesus factor polymorphism has been an evolutionary enigma since its discovery in 1939. Carriers of the rarer allele should be eliminated by selection against Rhesus positive children born to Rhesus negative mothers.
Jaroslav Flegr
doaj   +1 more source

CD4⁺ T Cells Are Key to Shaping a Protective Humoral Immunity in Primary Dengue 2 Virus Infection: Implications for Rational Vaccine Design

Vaccines
Background: Understanding the immune mechanisms that differentiate protective from pathogenic responses during dengue virus (DENV) infection is critical for effective vaccine development.
Angel E. Miranda-Santiago, Crisanta Serrano-Collazo, Lorna A. Cruz, Sandra Henein, Laura Alvarez, Teresa Arana, Jorge L. Sánchez-Bibiloni, Melween I. Martinez, Chiara Roman, Armando G. Burgos, Marcos J. Ramos-Benitez, Lourdes M. Caro-Rivera, James D. Brien, Amelia K. Pinto, Aravinda M. de Silva, Carlos A. Sariol   +15 more
doaj   +1 more source

Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics

Viruses, 2020
Recent Ebola virus (EBOV) outbreaks in West Africa and the Democratic Republic of the Congo have highlighted the urgent need for approval of medical countermeasures for treatment and prevention of EBOV disease (EVD).
Travis Warren, Elizabeth Zumbrun, Jessica M. Weidner, Laura Gomba, Franco Rossi, Roy Bannister, Jacqueline Tarrant, Matthew Reed, Eric Lee, Jo Lynne Raymond, Jay Wells, Joshua Shamblin, Kelly Wetzel, Ginger Donnelly, Sean Van Tongeren, Nicole Lackemeyer, Jesse Steffens, Adrienne Kimmel, Carly Garvey, Holly Bloomfield, Christiana Blair, Bali Singh, Sina Bavari, Tomas Cihlar, Danielle Porter   +24 more
doaj   +1 more source

Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2

bioRxiv, 2020
An outbreak of a novel coronavirus, now named SARS-CoV-2, causing respiratory disease and a ∼2% case fatality rate started in Wuhan, China in December 2019.
V. Munster, F. Feldmann, Brandi N. Williamson, Neeltje van Doremalen, L. Pérez-Pérez, Jonathan E. Schulz, Kimberly Meade-White, A. Okumura, Julie A. Callison, Beniah Brumbaugh, V. Avanzato, Rebecca Rosenke, P. Hanley, G. Saturday, D. Scott, E. Fischer, E. de Wit   +16 more
semanticscholar   +1 more source

Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA

Molecular Therapy: Nucleic Acids, 2015
One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump.
Richard Grondin, Pei Ge, Qingmin Chen, Jessica E Sutherland, Zhiming Zhang, Don M Gash, David K Stiles, Gregory R Stewart, Dinah W Y Sah, William F Kaemmerer   +9 more
doaj   +1 more source

A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques

Science Advances, 2020
Prime-only vaccination with ChAdOx1 MERS protects against HCoV-EMC/2012 in NHP and a variety of MERS-CoV strains in mice. Developing a vaccine to protect against the lethal effects of the many strains of coronavirus is critical given the current global ...
Neeltje van Doremalen, Elaine Haddock, F. Feldmann, Kimberly Meade-White, T. Bushmaker, R. Fischer, A. Okumura, P. Hanley, G. Saturday, N. Edwards, M. Clark, T. Lambe, S. Gilbert, V. Munster   +13 more
semanticscholar   +1 more source

B-Virus and Free-Ranging Macaques, Puerto Rico

Emerging Infectious Diseases, 2004
In Puerto Rico, risk for transmission of B-virus from free-ranging rhesus monkeys to humans has become a serious challenge. An incident with an injured rhesus monkey, seropositive for B-virus, resulted in inappropriate administration of antiviral ...
Kristen Jensen, Francisco Alvarado-Ramy, Janis González-Martínez, Edmundo Kraiselburd, Johnny Rullán   +4 more
doaj   +1 more source

Relationship between the ABO/Rh Blood Group Factors with Coronavirus Disease 2019 Severity and Mortality among Hospitalized Patients in Algeria: A Single-center Study

Journal of Advanced Lung Health
Introduction: The novel coronavirus causes the deadly disease, severe acute respiratory syndrome (SARS). Therefore, it is necessary to identify prognostic factors for patients hospitalized with SARS-coronavirus-2 infection to identify patients with ...
Abdelbassat Ketfi, Karima Zouai, Yacine Djagheri, Kamel Djenouhat, Rama Touahri   +4 more
doaj   +1 more source

Conformation of HIV-1 Envelope Governs Rhesus CD4 Usage and Simian-Human Immunodeficiency Virus Replication

mBio, 2022
Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is the preferred model system for vaccine development because SHIVs encode human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Envs)—a key target of HIV-1 ...
Geraldine Vilmen, Anna C. Smith, Hector Cervera Benet, Rajni Kant Shukla, Ross C. Larue, Alon Herschhorn, Amit Sharma   +6 more
doaj   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source