Results 51 to 60 of about 30,289 (203)

Sex-specific heritability of spontaneous lipid levels in an extended pedigree of Indian-origin rhesus macaques (Macaca mulatta). [PDF]

PLoS ONE, 2013
The rhesus macaque is an important model for human atherosclerosis but genetic determinants of relevant phenotypes have not yet been investigated in this species.
Amanda Vinson, Asia D Mitchell, David Toffey, Jacob Silver, Michael J Raboin   +4 more
doaj   +1 more source

Variable grouping patterns in primates: A test of the better competitor hypothesis in male Verreaux's sifaka (Propithecus verreauxi)

The Anatomical Record, EarlyView.
Abstract Intraspecific variation in social organization (IVSO) within primate populations can arise due to male mating competition. Verreaux's sifaka (Propithecus verreauxi) populations exhibit both single‐male and multi‐male groups, providing an opportunity to examine the relationship between male competitive ability and social organization.
Lemeng Li, Stacey R. Tecot, Rebecca J. Lewis   +2 more
wiley   +1 more source

Prediction of Human Serum Concentration–Time Profiles of Golimumab and Ustekinumab Using Pharmacokinetic Data From Common Marmosets With Assessment of Anti‐Drug Antibodies

Biopharmaceutics &Drug Disposition, EarlyView.
This study identified new optimal allometric scaling exponents for human PK prediction of monoclonal antibodies with linear PKs from marmoset PK data. In addition, immunogenicity in common marmosets was evaluated following the repeated dose of golimumab and ustekinumab, minimal anti‐drug antibodies were detected.
Ayaka Tajiri, Shogo Matsumoto, Nanami Furukawa, Kensuke Kagiyama, Hiroshi Ikeda, Kazumasa Fukasawa, Hiroki Takano   +6 more
wiley   +1 more source

Pooled genomic indexing of rhesus macaque [PDF]

Genome Research, 2005
Pooled genomic indexing (PGI) is a method for mapping collections of bacterial artificial chromosome (BAC) clones between species by using a combination of clone pooling and DNA sequencing. PGI has been used to map a total of 3858 BAC clones covering ∼24% of the rhesus macaque (Macaca mulatta) genome onto 4178 homologous loci in the human genome.
Aleksandar, Milosavljevic, Ronald A, Harris, Erica J, Sodergren, Andrew R, Jackson, Ken J, Kalafus, Anne, Hodgson, Andrew, Cree, Weilie, Dai, Miklos, Csuros, Baoli, Zhu, Pieter J, de Jong, George M, Weinstock, Richard A, Gibbs   +12 more
openaire   +2 more sources

Paternity testing for crab‐eating macaques and rhesus macaques using microsatellite markers

Animal Models and Experimental Medicine
Accurate macaque paternity identification is of great significance in various fields, yet relevant research remains scarce. Our study aimed to screen effective microsatellite markers for macaque paternity testing.
Yiming Yuan, Tianqi Sun, Lu Zhang, Wensheng Zhang, Teng Meng, Jianhua Zheng, Rui Zhang, Lei Lu, Zirong Pu, Yan Li, Yefeng Qiu   +10 more
doaj   +1 more source

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Neutrophil progenitor populations of rhesus macaques [PDF]

Journal of Leukocyte Biology, 2018
Abstract Captive-bred rhesus macaques of Indian origin represent one of the most important large animal models for infectious disease, solid organ transplantation, and stem cell research. There is a dearth of information defining hematopoietic development, including neutrophil leukocyte differentiation in this species using multicolor ...
Kim L, Weisgrau, Logan J, Vosler, Nicholas L, Pomplun, Jennifer M, Hayes, Heather A, Simmons, Kristen R, Friedrichs, Eva G, Rakasz   +6 more
openaire   +2 more sources

Pioneering the canine model in microbiota–gut–brain research for social and affective disorders

iMetaOmics, EarlyView.
This commentary highlights the translational potential of canine models in investigating the microbiota–gut–brain (MGB) axis, focusing on their relevance to human social cognition and affective disorders, including major depressive disorder and autism spectrum disorder.
Yun Yu, Qiuhan Wen, Xiaoyang Wang, Mengyu Song, Tifei Yuan, Feilong Deng, Jianmin Chai, Ying Li, Ya‐Ping Zhang   +8 more
wiley   +1 more source

Harnessing cracks in metal films: Design strategies for stretchable conductors

InfoMat, EarlyView.
In stretchable electronics, metal film‐based components function either as strain‐insensitive interconnects/electrodes or as strain‐sensitive sensors, both of which are governed by crack‐induced electromechanical responses, yet these two roles have often been discussed separately in previous reviews.
Ting Zhu, Kai Wu, Gang Liu, Jun Sun
wiley   +1 more source

Brain Charts for the Rhesus Macaque Lifespan

Abstract Recent efforts to chart human brain growth across the lifespan using large-scale MRI data have provided reference standards for human brain development. However, similar models for nonhuman primate (NHP) growth are lacking.
Xu T, Alldritt S, Ramirez J, de Wael RV, Bethlehem R, Seidlitz J, Nenning K, Smallwood J, Wang Z, Esper N, Franco A, Alexander-Bloch A, Amaral D, Amiez C, Balezeau F, Baxter M, Becker G, Bennett J, Berkner O, Blezer E, Brambrink A, Brochier T, Butler B, Byeon K, Campos L, Canet-Soulas E, Chalet L, Chen A, Cléry J, Constantinidis C, Cook D, Dehaene S, Dorfschmidt L, Drzewiecki C, Erdman J, Everling S, Falchier A, Fleysher L, Fox A, Freiwald W, Froesel M, Froudist-Walsh S, Fudge J, Funck T, Gacoin M, Gale D, flanagan J, Garin C, Griffiths T, Guedj C, Hadj-Bouziane F, Hamed SB, Harel N, Hartig R, Heuer K, Hiba B, Howell B, Jarraya B, Jung B, Kalin N, Karpf J, Kastner S, Klink P, Kovacs-Balint Z, Kroenke C, Kuchan M, Kwok SC, Lala K, Leopold D, Li G, Lindenfors P, Linn G, Mars R, Masiello K, Menon R, Messinger A, Meunier M, Mok K, Morrison J, Nacef J, Nagy J, Neudecker V, Neuringer M, Noonan M, Ortiz-Rios M, Perez-Zoghbi J, Pinsk M, Poirier C, Procyk E, Rajimehr R, Reader S, Rudko D, Rushworth M, Russ B, Sallet J, Sanchez M, Schmid M, Schwiedrzik C, Scott J, Sein J, Sharma K, Shmuel A, Styner M, Sullivan E, Thiele A, Todorov O, Toro R, Tsao D, Tusche A, Vlasova R, Wang L, Wang Z, Wang J, Weiss A, Wilson C, Yacoub E, Zarco W, Zhou Y, Zhu J, Petkov C, Margulies D, Fair D, Schroeder C, Milham M.   +123 more
europepmc   +6 more sources