Results 51 to 60 of about 43,519 (198)

Rhesus Macaque iPSC Generation and Maintenance [PDF]

Current Protocols in Stem Cell Biology, 2017
AbstractThe rhesus macaque (Macaca mulatta) is physiologically and phylogenetically similar to humans, and therefore represents an invaluable model for the pre‐clinical assessment of the safety and feasibility of iPSC‐derived cell therapies. The use of an excisable polycistronic lentiviral STEMCCA vector to reprogram rhesus fibroblasts or bone marrow ...
Ravi Chandra, Yada, So Gun, Hong, Yongshun, Lin, Thomas, Winkler, Cynthia E, Dunbar   +4 more
openaire   +2 more sources

Rhesus macaque and Cynomolgus macaque cohorts.

, 2013
Rhesus macaque and Cynomolgus macaque cohorts.
Anne M. Wertheimer (359266), Alfred Legasse (257296), Kristy O. Murray (205263), Jerald Sprague (359269), Clayton A. Wiley (359272), Guruprasad Medigeshi (359268), Michael K. Axthelm (359276), Janko Nikolich-Žugich (3217572), Jennifer L. Uhrlaub (143165), Alec Hirsch (359267), Peter Didier (359274), Jennifer Wilk (359271), Robert B. Tesh (122472), Scott W. Wong (359277)   +13 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Macaque-specific adaptations in SIV CA and Vif.

, 2016
Comparison of SIVmfa protein sequence (bolded) to related isolates of SIV and HIV-2. (A) Residues 79–100 of CA (based on SIVmac239 numbering) representing strains used in Fig 1.
Andrea Kirmaier (243219), Kevin R. McCarthy (411580), Welkin E. Johnson (243232)   +2 more
core   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

CYP1B1 is Polymorphic in Cynomolgus and Rhesus Macaques

Journal of Veterinary Medical Science, 2011
Cytochrome P450 (CYP) 1B1 is involved in the metabolic activation of various procarcinogens, and some CYP1B1 genetic variants alter CYP1B1-dependent procarcinogen metabolism. Cynomolgus and rhesus macaques are frequently used in toxicity tests due to their evolutionary closeness to humans. In this study, we attempted to identify CYP1B1 genetic variants
UNO, Yasuhiro, MATSUSHITA, Akinori, YAMAZAKI, Hiroshi   +2 more
openaire   +3 more sources

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

Rhesus Macaque TRAV and TRDV genes

, 2016
TRAV and TRDV genes extracted from the rhesus macaque genome. The gene features reported include L-PART1, V-INTRON, V-EXON, V-HEPTAMER, V-SPACER, and V-NONAMER.
David M. Lewinsohn (266240), Roth, Benjamin F., Ford, Julia C., Crank, Hugh, Picker, Louis J., Benjamin F. Roth (3310326), Deborah A. Lewinsohn (363574), William Hildebrand (264375), Lewinsohn, Deborah A., McMurtrey, Curtis, Katherine B. Hammond (843986), Pradyot Dash (194289), Jeffrey J. Stanton (3310341), Hammond, Katherine B., Greenaway, Hui Yee, Bae, Joseph Y., Venturi, Vanessa, Adams, Erin J., Marielle C. Gold (363563), Legasse, Alfred W., Louis J. Picker (3140679), Hansen, Scott G., Lewinsohn, David M., Byung S. Park (347249), Shaheed Abdulhaqq (3310365), Michael K. Axthelm (359276), Gold, Marielle C., Burwitz, Benjamin J., Jonah B. Sacha (539908), Curtis McMurtrey (3310347), Abdulhaqq, Shaheed, Erin J. Adams (253263), Melanie J. Harriff (363573), David W. Morrow (3310329), Monica Kurniawan (3310344), Sobhan Roy (3310335), Roy, Sobhan, Paul G. Thomas (194304), Hildebrand, William, Joseph Y. Bae (3310359), Dash, Pradyot, Reed, Jason, S., Greene, Justin, M. (3310389), Julia C. Ford (3310362), Guangwu Xu (3310338), Thomas, Paul G., Wu, Helen L., Dang, Thurston H., Benjamin J. Burwitz (36131), Alfred W. Legasse (3140685), Hui Yee Greenaway (3310350), Xu, Guangwu, Axthelm, Michael K., Morrow, David W., Sacha, Jonah B., Greene, Justin, M., Walid Awad (3310353), Vanessa Venturi (182536), Helen L. Wu (843985), Reed, Jason, S. (3310386), Scott G. Hansen (843989), Awad, Walid, Kurniawan, Monica, Harriff, Melanie J., Stanton, Jeffrey J., Park, Byung S., Hugh Crank (3310332), Thurston H. Dang (3310356)   +67 more
core   +1 more source

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Long-read structural variant discovery and targeted short read genotyping enables population scale characterization of structural variation in rhesus macaques

Genome Biology
Background Due to their close evolutionary relationship with humans, rhesus macaques are an important pre-clinical model. While genetic diversity driven by short nucleotide variation has long been studied in rhesus macaques, there is comparatively little
Karina Ray, Christina Mulch, Samuel M. Peterson, Sebastian Benjamin, Nathan Gullicksrud, Adam J. Ericsen, Eric J. Vallender, Betsy M. Ferguson, Jeffrey D. Wall, Benjamin N. Bimber   +9 more
doaj   +1 more source