Results 91 to 100 of about 241,326 (244)

First‐in‐Human Study of a Long‐Acting GLP‐1 Receptor Agonist (TE‐8105) in Overweight or Obese Adults Without Type 2 Diabetes Mellitus

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have revolutionized weight management and are becoming essential for the treatment of obesity‐related medical conditions. This study aimed to determine the pharmacokinetics, preliminary pharmacodynamics, safety, and tolerability of a long‐acting GLP‐1 receptor agonist, TE‐8105, in overweight or
Ya‐Shan Chuang, Jon D. Wright, Mun‐Teng Wong, Kushal J Paneliya, Wei‐Shiung Yang, Hsing‐Mao Chu, Tse Wen Chang, Thomas M Polasek   +7 more
wiley   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source

Variability in a dominant block to SIV early reverse transcription in rhesus monkey cells predicts in vivo viral replication and time to death

Virology Journal, 2010
While it has long been appreciated that there is considerable variability in host containment of HIV/SIV replication, the determinants of that variability are not fully understood.
Hsu Ariel, Chan Tiffany, Sundsvold TJ, Lim So-Yon, Rogers Thomas F, Letvin Norman L   +5 more
doaj   +1 more source

Demographic buffering in natural populations: A multi‐level perspective

Journal of Animal Ecology, Volume 95, Issue 8, Page 1298-1310, August 2026.
We introduce a multi‐level framework that unites stochastic elasticities with nonlinear selection to test demographic buffering. Applying it across mammals reveals a key insight: ecological robustness to variability often decouples from evolutionary constraint, reshaping how we understand resilience under environmental stochasticity.
Gabriel Silva Santos, Samuel J. L. Gascoigne, André Tavares Corrêa Dias, Maja Kajin, Roberto Salguero‐Gómez   +4 more
wiley   +1 more source

Aplicação do método de comparação dos índices de neutralização à identificação intratípica de poliovírus dos tipos 1 e 3, utilizando culturas de células Hep-2 Application of the neutralization index comparison technique to the intratypic serodifferentiation of type 1 and 3 poliovirus strains, using Hep-2 cell cultures

Revista de Saúde Pública, 1975
Foram estudadas culturas primárias de células renais de macaco rhesus (RMK) e culturas de células contínuas Hep-2, comparativamente em provas de identificação sorológica intratípica de 28 estirpes de poliovírus dos tipos 1 e 3, pelo método da "comparação
Klaus E. Stewien, José P. G. de Lacerda
doaj   +1 more source

Rhesus Monkey Lymphoma

Definitions, 2020

semanticscholar   +1 more source

Pathophysiological and Molecular Features of DXd ADC‐Related Interstitial Pneumonitis in Cynomolgus Monkeys

Cancer Science, Volume 117, Issue 8, Page 2305-2316, August 2026.
An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai, Takuma Iguchi, Kentaro Kubota, Ken Sakurai, Yoshimi Tsuchiya, Katsuyoshi Chiba   +5 more
wiley   +1 more source

Watching the eye with Mars in sight

Experimental Physiology, EarlyView.
Peter zu Eulenburg, Lonnie Petersen, Damian M. Bailey   +2 more
wiley   +1 more source

Distinct High‐Gamma Signals in Primate Prefrontal Cortex Differentiate Cue Information, Preference Revision, and Expected Reward During Value‐Based Decisions

European Journal of Neuroscience, Volume 64, Issue 3, August 2026.
High‐gamma activity in primate prefrontal cortex differentiates multiple task‐defined variables during sequential decision‐making, reflecting population‐level dynamics consistent with mixed‐selectivity representations. ABSTRACT Understanding how prefrontal cortex (PFC) signals evolve over time to support decision‐making requires characterizing both the
Renée Johnston, Chadwick Boulay, Laurence Hunt, Steven W. Kennerley, Adam J. Sachs   +4 more
wiley   +1 more source