Results 51 to 60 of about 2,245,112 (263)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Serum B cell activating factor (BAFF) and sarcoidosis activity

The Turkish Journal of Gastroenterology, 2021
Objectives: This study aims to determine the relationship between the severity of sarcoidosis and serum B-cell activating factor (BAFF) concentrations.
Kamila HASHEMZADEH, Maryam FATEMIPOUR, Seyede ZAHRA MIRFEIZI, Mohammadhasan JOKAR, Zhaleh SHARIATI SARABI, Mohammad-Reza HATEF FARD, Houshang RAFATPANAH, Mandana KHODASHAHI   +7 more
doaj  

Associations between cardiovascular risk factors, disease activity and cardiorespiratory fitness in patients with inflammatory joint disease: a cross-sectional analysis

BMC Sports Science, Medicine and Rehabilitation, 2023
Background Inflammatory joint diseases (IJD) are accompanied by an increased risk of cardiovascular disease (CVD). Cardiorespiratory fitness (CRF) is a modifiable CVD risk factor and low levels of CRF associate with an elevated CVD risk. This study aimed
Kristine Røren Nordén, Anne Grete Semb, Hanne Dagfinrud, Jonny Hisdal, Sigrid Ødegård, Joseph Sexton, Camilla Fongen, Jon Skandsen, Thalita Blanck, George S. Metsios, Anne Therese Tveter   +10 more
doaj   +1 more source

Role of Nigella sativa in the Management of Osteoarthritis: A Systematic Review

Traditional and Integrative Medicine, 2023
Because of the anti-inflammatory properties of thymoquinone (TQ), as the main bioactive substance of Nigella sativa, this systematic review aimed at assessing the therapeutic effects of N.
Mozhdeh Ghamari, Masoumeh Salari, Mandana Khodashahi   +2 more
doaj   +1 more source

High burden of rheumatic diseases in Lebanon: A COPCORD study

, 2012
Aim: To estimate the prevalence of rheumatic diseases in Lebanon and to explore their distribution by geographic location, age, and gender. Method: Using the Community Oriented Program for the Control of Rheumatic Diseases (COPCORD) methodology, a random
Dana R., Hamdan O., Uthman I., Issa Z., Slim Z.N., Habib R.R., Assi M., Chaaya M., Arayssi T.   +8 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Preventative Effect of a Flavonoid, Enzymatically Modified Isoquercitrin on Ocular Symptoms of Japanese Cedar Pollinosis

Allergology International, 2009
Background: Flavonoids are nutrients that exert anti-allergic effects. We investigated the preventative effect of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve the symptoms of Japanese cedar pollinosis. Methods: In a parallel-group,
Toru Hirano, Mari Kawai, Junsuke Arimitsu, Masako Ogawa, Yusuke Kuwahara, Keisuke Hagihara, Yoshihito Shima, Masashi Narazaki, Atsushi Ogata, Mihoko Koyanagi, Tomoko Kai, Ryosuke Shimizu, Masamitsu Moriwaki, Yukio Suzuki, Satoshi Ogino, Ichiro Kawase, Toshio Tanaka   +16 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Role of Extracellular Matrix and Hydrogels in Mesenchymal Stem Cell Chondrogenesis and Cartilage Regeneration

Life, 2022
Diseases associated with articular cartilage disintegration or loss are still therapeutically challenging. The traditional treatment approaches only alleviate the symptoms while potentially causing serious side effects. The limited self-renewal potential
Magdalena Strecanska, Lubos Danisovic, Stanislav Ziaran, Michaela Cehakova   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source