Results 111 to 120 of about 668,242 (377)

Culture Positive Brucella Endocarditis in a Case of Baloon Mitral Valvotomy [PDF]

, 2011
Brucella endocarditis is a rare condition which occurs as a focal complication in chronic brucellosis cases. We report a rare brucella endocarditis case in a RVHD patient. A 26 years old male was admitted with fever on off for almost one year.
Aundhkar, S, Ghorpade, MV, Pawar, SK
core  

Tuberculosis in prisons in sub-Saharan Africa--a potential time bomb. [PDF]

, 2011
No ...
Bates, Matthew, Kapata, Nathan, Mwaba, Peter, O'Grady, Justin, Zumla, Alimuddin   +4 more
core   +1 more source

A Cost-Effectiveness Analysis of a Program to Control Rheumatic Fever and Rheumatic Heart Disease in Pinar del Rio, Cuba

PLoS ONE, 2015
Background Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) persist in many low- and middle-income countries. To date, the cost-effectiveness of population-based, combined primary and secondary prevention strategies has not been assessed. In
D. Watkins, Mercy Mvundura, P. Nordet, B. Mayosi   +3 more
semanticscholar   +1 more source

Novel Wire‐Assisted Mitral Commissurotomy Reduces Valve Crossing Time Compared to Inoue‐Balloon Technique of Treating Mitral Stenosis, Randomized Controlled Trial (CROSSVal)

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Percutaneous mitral commissurotomy (PMC) of mitral stenosis is routinely performed by the Inoue balloon technique (IBT) which may be challenging with respect to valvular crossing. Using a novel wire‐assisted method (WAM) may improve feasibility and time efficiency. Aims In a randomized clinical trial, we compared the feasibility and
Chala Fekadu Oljira, Erik JS Packer, Håvard Dalen, Tom Roar Omdal, Rune Haaverstad, Adane Petros, Dejuma Yadeta, Eskindir Loha, Thomas Dolven, Hans Martin Flade, Arne Skagseth, Nigussie Bogale   +11 more
wiley   +1 more source

Rheumatic fever: New ideas in diagnosis and management

SA Heart Journal, 2017
Rheumatic heart disease remains a major cause of disability and death in developing countries. Careful re-analysis of mid-20th century data as well as the juxtaposition of well-funded research units and populations at risk have generated information that
John Lawrenson
doaj   +1 more source

Clinical Outcomes in 3343 Children and Adults with Rheumatic Heart Disease from 14 Low and Middle Income Countries: 2-Year Follow-up of the Global Rheumatic Heart Disease Registry (the REMEDY study) [PDF]

, 2016
Background: There are few contemporary data on the mortality and morbidity associated with rheumatic heart disease or information on their predictors.
Abdissa, Senbeta G, Abul Fadl, Azza, Adeoye, Abiodun M, Al-Kebsi, Mohammed M, Amusa, Ganiyu A, Begna, Dufera M, Bode-Thomas, Fidelia, Cupido, Blanche, Damasceno, Albertino, Daniel, Wandimu, Daniels, Rezeen, Desta, Araya G, ElHassan, Huda, ElSayed, Ahmed, Engel, Mark E, Francis, Veronica, Gitura, Bernard, Goshu, Dejuma Yadeta, Haileamlak, Abraham, Hugo-Hamman, Christopher, Ibrahim, Ahmed S, Ige, Olukemi, Islam, Shofiqul, Karthikeyan, Ganesan, Kennedy, Neil, Lwabi, Peter, Mackie, Pam, Mauff, Katya, Mayosi, Bongani M, Misra, Rajeev, Mntla, Pindile S, Mocumbi, Ana Olga, Mondo, Charles, Mucumbitsi, Joseph, Musuku, John, Ogah, Okechukwu S, Ogendo, Stephen, Ojji, Dike B, Okeahialam, Basil, Okello, Emmy, Olunuga, Taiwo, Rangarajan, Sumathy, Sani, Mahmoud U, Shasho, Bekele A, Sheta, Sahar S, Sutton, Christopher, Teo, Koon, Yilgwan, Christopher C, Yusuf, Salim, Zühlke, Liesl   +49 more
core   +1 more source

Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This single‐center, randomized, open‐label bioequivalence program compared two fixed‐dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting and fed conditions. A three‐period, partially replicated crossover design was used for the
Menghan Ye, Rui Zhang, Jing Wan, Jinping Zhou, Pengpeng Guo, Dianwen Yu, Peixia Li, Yani Liu, Shaojun Shi   +8 more
wiley   +1 more source

Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes

Drugs in R&D
Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis.
Usman Nakakana, Alimamy Serry-Bangura, Bassey Effiom Edem, Pietro Tessitore, Leonardo Di Cesare, Danilo Gomes Moriel, Audino Podda, Iris Sarah De Ryck, Ashwani Kumar Arora   +8 more
doaj   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik, Ainhoa Gomez‐Lumbreras, Guilherme Del Fiol, Kensaku Kawamoto, Katy E. Trinkley, Thomas Reese, Aubrey Jones, Daniel C. Malone   +7 more
wiley   +1 more source

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen, Menno van Diemen, Liza Botros, Ingrid Tomljanovic, Hind Achbo, Dimitra Eleftheriou, Paul Willem Schenk, Naomi Bertine Klarenbeek, Derek William Gilroy, Manon Aleida Adriana Jansen, Matthijs Moerland   +10 more
wiley   +1 more source