Results 101 to 110 of about 927,717 (352)

Coronary Artery Disease in Rheumatic and Non-Rheumatic Valvular Heart Disease

Journal of Rawalpindi Medical College, 2018
Background:To study the prevalence of coronary artery disease (CAD) in patients undergoing valve surgery for rheumatic and non-rheumatic valvular heart disease.
Uzma Gul, Asim Javed, Muhammad Abdus Salam Azad, Qaiser Khan   +3 more
doaj  

Prevalence and pattern of rheumatic valvular heart disease in Africa: Systematic review and meta-analysis, 2015-2023, population based studies.

PLoS ONE
BackgroundRheumatic heart disease is a global health concern with a persistently high incidence in developing countries, including Africa. It has a significant economic, morbidity, and mortality burden, particularly for children and young adults during ...
Seid Mohammed Abdu, Altaseb Beyene Kassaw, Amare Abera Tareke, Gosa Mankelkl, Mekonnen Belete, Mohammed Derso Bihonegn, Ahmed Juhar Temam, Gashaw Abebe, Ebrahim Msaye Assefa   +8 more
doaj   +1 more source

Quadrivalvular rheumatic heart disease

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging, 2019
Rarely, rheumatic heart disease (RHD) involves all the four valves and causes could be rheumatic, congenital, infective, or degenerative. Here, we report a case of a 42-year-old female known case RHD for 30 years and underwent closed mitral ...
Deepak Ramchand Nenwani, Gnanavelu Ganesan, S Venkatesan, S Saravana Babu   +3 more
doaj   +1 more source

The great simulator [PDF]

, 1993
Cardiac myxoma often simulates multisystem disease and initially defies diagnosis. In this paper, we present three cases of cardiac myxoma in adults.
Aquilina, Oscar, Fenech, Frederick F., Mallia, Carmel   +2 more
core  

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source