Results 271 to 280 of about 410,628 (308)
Some of the next articles are maybe not open access.
The Lancet, 2001
Rheumatoid arthritis is a systemic inflammatory disorder that mainly affects the diarthrodial joint. It is the most common form of inflammatory arthritis, and has a substantial societal effect in terms of cost, disability, and lost productivity. Although the pathogenesis of rheumatoid arthritis remains incompletely understood, much insight into the ...
D M, Lee, M E, Weinblatt
openaire +4 more sources
Rheumatoid arthritis is a systemic inflammatory disorder that mainly affects the diarthrodial joint. It is the most common form of inflammatory arthritis, and has a substantial societal effect in terms of cost, disability, and lost productivity. Although the pathogenesis of rheumatoid arthritis remains incompletely understood, much insight into the ...
D M, Lee, M E, Weinblatt
openaire +4 more sources
Current Opinion in Rheumatology, 1998
Rheumatoid arthritis (RA) is a common systemic, inflammatory, rheumatic disease of unknown etiology manifest by a chronic symmetric polyarthritis, particularly involving the small distal joints. Pathogenesis may involve inappropriate T-cell activation or lack of appropriate inhibition, although newer theories center on the importance of cytokines and ...
openaire +5 more sources
Rheumatoid arthritis (RA) is a common systemic, inflammatory, rheumatic disease of unknown etiology manifest by a chronic symmetric polyarthritis, particularly involving the small distal joints. Pathogenesis may involve inappropriate T-cell activation or lack of appropriate inhibition, although newer theories center on the importance of cytokines and ...
openaire +5 more sources
Baillière's Clinical Rheumatology, 1988
The results of family and twin studies suggest that RA may result from an interaction between an oligogenic susceptibility and unknown environmental factors. Part of this genetic predisposition is accounted for by genes within the MHC where there is a well-documented association with HLA-DR4.
D M, Grennan, P A, Sanders
openaire +2 more sources
The results of family and twin studies suggest that RA may result from an interaction between an oligogenic susceptibility and unknown environmental factors. Part of this genetic predisposition is accounted for by genes within the MHC where there is a well-documented association with HLA-DR4.
D M, Grennan, P A, Sanders
openaire +2 more sources
Current Opinion in Immunology, 1991
The immunopathogenesis of rheumatoid arthritis is discussed in two ways. First, we consider the major question of whether T cells are likely to drive the disease. Second--and assuming T cells to be important--we discuss available data on the components of the trimolecular complex (major histocompatibility complex class II-antigen-T-cell receptor ...
L, Klareskog +3 more
openaire +2 more sources
The immunopathogenesis of rheumatoid arthritis is discussed in two ways. First, we consider the major question of whether T cells are likely to drive the disease. Second--and assuming T cells to be important--we discuss available data on the components of the trimolecular complex (major histocompatibility complex class II-antigen-T-cell receptor ...
L, Klareskog +3 more
openaire +2 more sources
Foot and Ankle Clinics, 2007
This article reviews rheumatoid arthritis, a chronic disease that primarily targets the joints, its treatment and antirheumatic drugs.
openaire +2 more sources
This article reviews rheumatoid arthritis, a chronic disease that primarily targets the joints, its treatment and antirheumatic drugs.
openaire +2 more sources
Critical Care Clinics, 2002
Rheumatoid arthritis (RA) is a systemic, debilitating disease characterized by chronic polyarticular inflammation that leads to erosion of joint and bones and to significant extra-articular, systemic, and cardiopulmonary manifestations. RA affects the patient's psychologic and social well-being as well as physical activity.
Harakh V, Dedhia, Anthony, DiBartolomeo
openaire +2 more sources
Rheumatoid arthritis (RA) is a systemic, debilitating disease characterized by chronic polyarticular inflammation that leads to erosion of joint and bones and to significant extra-articular, systemic, and cardiopulmonary manifestations. RA affects the patient's psychologic and social well-being as well as physical activity.
Harakh V, Dedhia, Anthony, DiBartolomeo
openaire +2 more sources
Zeitschrift für Rheumatologie, 2017
Therapy reduction in rheumatoid arthritis (RA) is still a challenge for physicians as well as for patients. Effective therapy with subsequent achievement of low disease activity or even remission is achievable for numerous patients using currently available treatment options.
D, Aletaha, A, Kerschbaumer
openaire +2 more sources
Therapy reduction in rheumatoid arthritis (RA) is still a challenge for physicians as well as for patients. Effective therapy with subsequent achievement of low disease activity or even remission is achievable for numerous patients using currently available treatment options.
D, Aletaha, A, Kerschbaumer
openaire +2 more sources
Zeitschrift für Rheumatologie, 2018
Rheumatoid arthritis (RA) is a chronic and progressive systemic disease of the connective tissue, which is particularly manifested with destructive alterations to the joints. Inflammatory reactions in the synovium lead to the influx of peripheral inflammatory cells as well as the activation of local cells.
E, Neumann +3 more
openaire +2 more sources
Rheumatoid arthritis (RA) is a chronic and progressive systemic disease of the connective tissue, which is particularly manifested with destructive alterations to the joints. Inflammatory reactions in the synovium lead to the influx of peripheral inflammatory cells as well as the activation of local cells.
E, Neumann +3 more
openaire +2 more sources
Annals of Internal Medicine, 2019
Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease characterized by painful, swollen joints that can severely impair physical function and quality of life. The presenting symptoms of musculoskeletal pain, swelling, and stiffness are common in clinical practice, so familiarity with diagnosing and managing RA is crucial ...
openaire +2 more sources
Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease characterized by painful, swollen joints that can severely impair physical function and quality of life. The presenting symptoms of musculoskeletal pain, swelling, and stiffness are common in clinical practice, so familiarity with diagnosing and managing RA is crucial ...
openaire +2 more sources
Hospital Practice, 1979
Why self-perpetuating joint destruction is intermittent in some patients and unrelenting in others remains largely unknown, but progress has been made in identifying the different types of clinical course and tailoring specific treatment regimens for each.
openaire +2 more sources
Why self-perpetuating joint destruction is intermittent in some patients and unrelenting in others remains largely unknown, but progress has been made in identifying the different types of clinical course and tailoring specific treatment regimens for each.
openaire +2 more sources