Results 281 to 290 of about 1,101,764 (406)

A Pilot Study to Evaluate Neurodevelopmental Outcomes in a Pediatric Cohort With Genodermatoses

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Our study aimed to evaluate cognitive function in individuals with genetic skin disorders involving neuroectoderm (n = 8) compared to individuals with only ectoderm or mesoderm (n = 16) involvement. We hypothesized that neuroectodermal involvement would result in poorer neurocognitive performance.
Sneha A. Rangu, Kierstin Keller, Dong Li, Hope Thomas, Nora O'Connor, Abbas F. Jawad, Allison Thomas, Nina H. Thomas, Hakon Hakonarson, Leslie Castelo‐Soccio, Sarah E. Sheppard   +10 more
wiley   +1 more source

Amyloid Disease following Rheumatoid Arthritis with Advanced Arterial Calcification [PDF]

, 1959
A. M. Denman, E. C. Warner
openalex   +1 more source

Hereditary Multiple Osteochondromas and Acute Lymphoblastic Leukemia: A Possible Role for EXT1 and EXT2 in Hematopoietic Malignancies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi, Carmela Fusco, Rosamaria Mura, Carla Cerruto, Leonardo D'Agruma, Salvatore Carnazzo, Marco Castori, Salvatore Savasta   +7 more
wiley   +1 more source

Aortic Regurgitation and Rheumatoid Arthritis. [PDF]

JACC Case Rep
Selinski C, Addetia K.
europepmc   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes. [PDF]

Sci Adv
Hiitola E, Korhonen J, Kokkonen H, Koskela J, Kankainen M, Alakuijala M, Liu A, Lundgren S, Häppölä P, Almusa H, Ellonen P, Savola P, Kelkka T, Leirisalo-Repo M, Koivuniemi R, Peltomaa R, Pirilä L, Isomäki P, Kauppi M, Kaipiainen-Seppänen O, Starskaia I, Virtanen AT, Lahesmaa R, Silvennoinen O, FinnGen, Genovese G, Ganna A, Rantapää-Dahlqvist S, Mustjoki S, Myllymäki M.   +29 more
europepmc   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Vagotomy and the incidence of rheumatoid arthritis and osteoarthritis: a Danish register-based study. [PDF]

Arthritis Res Ther
Baker MC, Nagy D, Tamang S, Horváth-Puhó E, Sørensen HT.   +4 more
europepmc   +1 more source

Rheumatoid Arthritis [PDF]

Postgraduate Medical Journal, 1948
openaire   +2 more sources

Improved husbandry measures to enhance reproducibility of wound healing studies in the Leprdb/db mouse

Animal Models and Experimental Medicine, EarlyView.
Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat, Brian P. David, Junhe Shi, Angela Xu, Terry W. Moore, Lin Chen, Luisa A. DiPietro   +6 more
wiley   +1 more source