Results 41 to 50 of about 372,619 (295)

Purification of a Rheumatoid Factor.

Experimental Biology and Medicine, 1958
SummaryA macroglobulin was purified from sera of individuals with rheumatoid arthritis which agglutinated sensitized sheep erythrocytes and fixed gamma globulin-latex particle suspensions. Tentative evidence for the homogeneity of a preparation was furnished. The isolated macroglobulin is a component of the rheumatoid factor. The latter is a mixture of
Richard H. Freyberg, O. M. Federico, Ralph Heimer   +2 more
openaire   +3 more sources

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. [PDF]

, 2011
BackgroundRheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA).
Alfredsson, Lars, Ding, Bo, Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study group, Klareskog, Lars, Ong, Rick TH, Padyukov, Leonid, Rönnelid, Johan, Seddighzadeh, Maria, Seielstad, Mark   +8 more
core  

Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis. [PDF]

, 2014
BackgroundIndividuals with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease, partly due to systemic inflammation and endothelial dysfunction.
Del Puerto, Gus, Ganz, Peter, Graf, Jonathan, Grunfeld, Carl, Hsue, Priscilla Y, Imboden, John, Nitta, Elaine, Scherzer, Rebecca, Schnell Heringer, Amanda, Shigenaga, Judy, Wu, Yuaner   +10 more
core   +2 more sources

Effects of Non‐Aspirin Nonsteroidal Anti‐Inflammatory Drugs on Acute Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite celecoxib, a cyclooxygenase‐2 inhibitor, promoting functional recovery from intracerebral hemorrhage (ICH) by reducing inflammation‐mediated perihematomal edema in rat models, the evidence of its effects on patient outcomes remains limited.
Shin‐Joe Yeh, Sung‐Chun Tang, Li‐Kai Tsai, Jiann‐Shing Jeng   +3 more
wiley   +1 more source

Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia [PDF]

, 2004
We previously demonstrated prolonged, profound CD4+ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy. Poor reconstitution could result either from reduced de novo T-cell production through the thymus or from poor
Bingham, S.J., Brown, A.K., Buch, M., Douglas, S.H., Emery, P., Fearon, U., Field, S.L., Isaacs, J.D., Lawson, C.A., Ma, D., Maltby, S.L., Markham, A.F., Masurel, A., McGonagle, D., Moore, J., Morgan, A.W., Papadaki, H.A., Patel, P., Ponchel, F., Protheroe, A., Quinn, M., Short, K., Snowden, J., Straszynski, L., van Laar, J.M., Veale, D.J., Verburg, R.J.   +26 more
core   +2 more sources

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

Rheumatoid factors and glomerulonephritis

Clinical and Experimental Immunology, 1990
SUMMARY It is presently unknown whether rheumatoid factors have a pathogenic role in the development of various types of glomerulonephritis with immune deposits. Three isotypes of rheumatoid factors (RFs), which are autoantibodies to IgG, were measured using the solid-phase fluorescence immunoassay in sera from patients with diffuse ...
Takao Kuramoto, Masayuki Endoh, Mitsunori Yagame, Yasuo Nomoto, Masanobu Miyazaki, Naohiro Yano, Kazuhiko Eguchi, Takao Suga, M Miura, Hideto Sakai, Y. Matsumoto   +10 more
openaire   +4 more sources

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis. [PDF]

, 2019
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption that may be therapeutically targetable. Among them, glucose metabolism and glycolytic intermediaries seem to have an important role in fibroblast-like ...
de Oliveira, Patricia Gnieslaw, Farinon, Mirian, Guma, Monica, Miyamoto, Shigeki, Sanchez-Lopez, Elsa   +4 more
core   +1 more source