Results 121 to 130 of about 60,402 (271)

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Abatacept reduces levels of switched memory B cells, autoantobodies, and immunoglobulins in patients with Rheumatoid Arthritis [PDF]

, 2014
Objective. Abatacept (ABA) is a chimeric molecule, able to block the CD28-mediated costimulatory pathway. To evaluate the hypothesis that, through this mechanism of action, ABA may down-modulate the immune responses of B lymphocytes in rheumatoid ...
A.PEDRINI, A.TINCANI, D.RICOTTA, L.CAIMI, L.PAOLINI, M.SCARSI, P.AIRO’, S.PIANTONI   +7 more
core  

Investigating the Ligand‐Binding Properties of N‐arylbenzimidazoles as Novel Elastase Inhibitors

ChemMedChem, EarlyView.
A series of novel N‐[(3,5‐dimethylphenyl)methyl]‐1H‐benzimidazole derivatives is designed, synthesized, and evaluated for inhibitory activity against elastase. Several compounds demonstrate an antielastase activity, including the N‐(2‐bromophenyl)‐2‐(6‐chloro‐1‐(3,5‐dimethylbenzyl)‐1H‐benzo[d]imidazol‐2‐ylthio)acetamide, showing the greatest potency ...
Giovanna Pitasi, Sonia Floris, Francesca Mancuso, Giulia Savoca, Rosaria Gitto, Antonella Fais, Laura De Luca   +6 more
wiley   +1 more source

Polygenic risk scores of rheumatoid arthritis associated with seropositivity and bone erosions in a Taiwanese population

Scientific Reports
Polygenic risk scores (PRS) are widely used to estimate disease risks and predict clinical outcomes. However, ethnic differences exist worldwide. We aimed to use PRS for predicting the development of rheumatoid arthritis (RA) in a Taiwanese population ...
Ting-Shuan Wu, Yen-Ju Chen, Chia-Ni Hsiung, Chien-Lin Mao, Chia-Yi Wei, I-Chieh Chen, Chung-Mao Kao, Tzu-Hung Hsiao, Wen-Nan Huang, Yi-Hsing Chen, Yi-Ming Chen   +10 more
doaj   +1 more source

Rheumatoid factor and anti-cyclic citrullinated peptide antibody levels decline in rheumatoid arthritis patients treated with Janus kinase inhibitors or biological disease-modifying anti-rheumatic drugs

Journal of Rheumatic Diseases
Objective: We aimed to investigate the rate of decline in serum anti-cyclic citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) levels in rheumatoid arthritis (RA) patients treated with Janus kinase inhibitors (JAKis) compared with ...
Bo Young Kim, Ji-Won Kim, Hwajeong Lee, Sung-Hoon Park, Seong-Kyu Kim, Jung-Yoon Choe   +5 more
doaj   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Relationship Between Trough Levels of Anti-Infliximab and Serum Biomarkers in Patients With Rheumatoid Arthritis

Acta Medica Iranica
Rheumatoid arthritis is a chronic condition, characterized by the expression of antibody against self-antigens. Inflammatory cell of synovial tissues secreted numerous cytokines, include tumor necrosis factor alpha.
Sura Mohammed Lateef, Ahmed Abdul-Hassan Abbas, Mohammed Hadi Alosami   +2 more
doaj   +1 more source

The diagnostic value of N-acetyl-β-D-glucosaminidase and microalbumin concentrations in rheumatoid arthritis [PDF]

Journal of Medical Biochemistry, 2007
The purpose of this research was to compare the diagnostic values of laboratory variables, to present quantitative evaluations of the diagnostic sifted test with reference to sensitivity and specificity, the predictive value of the positive and negative ...
Spasovski Dejan, Gruev Todor, Marina Nada, Čalovski Jordan, Percinkova Snežana, Osmani Baskim, Rajčevska Ljubinka, Čakalaroski Kočo, Sotirova Tatjana, Balkanov Svetlana, Slaninka-Micevska Maja   +10 more
doaj  

Serum levels of auto-antibodies (rheumatoid factor and anti-double stranded DNA) in Nigerian COVID-19 patients

The Egyptian Journal of Bronchology
Background A thorough understanding of how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to autoantibody development is essential to clarify the possibility of autoimmune disorders in COVID-19 patients. Consequently, this study
Haleemat Yejide Oladokun, Sheu Kadiri Rahamon, Surajudeen Adebayo Yaqub, AbdulFattah Adekunle Onifade, Ganiyu Olatunbosun Arinola   +4 more
doaj   +1 more source

PEMERIKSAAN RHEUMATOID FACTOR (RF) DENGAN LAJU ENDAP DARAH (LED) YANG MENINGKAT PADA PASIEN SUSPECT RHEUMATOID ARTHRITIS (RA)

Jurnal Medical Laboratory
ABSTRACT Rheumatoid Factor (RF) is a laboratory examination that measures the amount of RF antibodies in the blood serum. This examination is carried out in patients with suspected autoimmune diseases such as RA. To confirm the diagnosis. Rheumatoid Arthritis (RA) is not a definitive single diagnostic test.
null Risa Fitri Awaliah, null Apriani Apriani   +1 more
openaire   +1 more source