Results 241 to 250 of about 410,593 (361)

Chronic widespread pain prevalence in the general population: a systematic review [PDF]

, 2018
Ablin, Abusdal, Abusdal, Allison, Assumpção, Bannwarth, Barham, Bartley, Beasley, Bender, Benjamin, Bergman, Branco, Braveman, Buskila, Cabral, Carnes, Choudhury, Croft, Croft, Dragioti, Dueñas, Dueñas, Elm, Elzahaf, Fillingim, Flüß, Forseth, Freburger, Gaskin, Gerdle, Hagen, Henschke, Hiller, Hunt, Hurley, Jacobsson, Lee, Lee, Lindell, Macfarlane, Macfarlane, Macfarlane, Macfarlane, Mansfield, Mas, Nicholl, Okifuji, Pang, Papageorgiou, Perrot, Picavet, Pieretti, Ridder De, Rios, Riskowski, Roh, Roth, Santos, Schaefer, Schochat, Schochat, Scudds, Slavin, Soares, Tate, Toda, Topbas, Urwin, Vandenkerkhof, Walker-Bone, White, Wiesenfeld-Hallin, Wolfe, Wolfe   +74 more
core   +2 more sources

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Practical insights for the clinical implementation of the EULAR recommendations for patients with systemic lupus erythematosus. [PDF]

RMD Open
Parodis I, Fanouriakis A, Bortoluzzi A, Iking-Konert C, Weinmann-Menke J, San Román C, Levy RA, Rua-Figueroa I, Alexander T, Amoura Z.   +9 more
europepmc   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Correction: Results of an expert Delphi consensus from the Italian Society of Medical and Interventional Radiology (SIRM) and the Italian Society of Rheumatology (SIR) on standardized requesting and reporting magnetic resonance imaging in patients with suspected or known axial spondyloarthritis. [PDF]

Radiol Med
Salaffi F, Carotti M, Martino F, Filippucci E, Farah S, Ramonda R, Doria A, Caporali R, Govoni M, Sarzi-Puttini P, Batticiotto A, Ceccarelli L, Rossini M, Scarano E, Sconfienza LM, Vio S, Masciocchi C, Muda A, La Paglia E, De Filippo M, Zappia M, Gallazzi MB, D'Angelo S, Oliviero F, Di Carlo M, Barreca C, Canzoni M, Silvestri E, Aliprandi A, Barile A, Splendiani A, Giovagnoni A, Leone A, Gandolfo N.   +33 more
europepmc   +1 more source

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source

Filgotinib Effectiveness in Rheumatoid Arthritis: Observational Analysis of a Large Multicenter Cohort. [PDF]

Rheumatol Ther
Celletti E, Di Penta M, Ariani A, Parisi S, Andracco R, Raffeiner B, Ianniello A, Lo Gullo A, Molica Colella AB, Priora M, Paroli M, Lumetti F, Ravagnani V, Girelli F, Vitetta R, Volpe A, Scolieri P, Bezzi A, Ometto F, Visalli E, Farina A, Del Medico P, Bravi E, Colina M, Larosa M, Serale F, Franchina V, Molica Colella F, Ferrero G, Sandri G, Addimanda O, Reta M, Mascella F, Focherini MC, Fiorenza A, Rovera G, Giampietro C, Bernardi S, Mansueto N, Camellino D, Caccavale R, Nucera V, Sabatini E, Del Biondo P, Ditto MC, Platè I, Adorni G, Di Donato E, Santilli D, Lucchini G, Amato G, De Lucia F, Dal Bosco Y, Foti R, Smerilli G, Bianchi G, Foti R, Arrigoni E, Marchetta A, Bixio R, Bruzzese V, Fusaro E, Giuggioli D, Salvarani C, Cipollone F, Becciolini A.   +65 more
europepmc   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Successful treatment of refractory chilblain lupus erythematosus with bosentan. [PDF]

Rheumatology (Oxford)
Gunawardana S, Clarke AJ, Lloyd-Lavery A, Dubey S.   +3 more
europepmc   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

Advanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang, Yi Liu, Ziying Sun, Jia Li, Zhihao Lu, Jiayuan Huang, Shixian Hu, Peihua Cao, Xiaolong Cao, Shangru Li, Jianzhao Ruan, Jinhui Liu, Jingyu Xie, Haitao Sun, Tianyu Chen, Shengfa Li, Zhaohua Zhu, Zhibo Wen, Rocky S. Tuan, David John Hunter, Zhong Alan Li, Dongquan Shi, Changhai Ding   +22 more
wiley   +1 more source