Results 171 to 180 of about 37,461 (298)

Enhanced Early Detection of Allergic Rhinitis: A Prospective Study on a Symptom‐Based Predictive Model

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Allergic rhinitis (AR) and non‐allergic rhinitis (NAR) share overlapping symptoms but differ in pathophysiology and treatment. Current AR diagnosis relies on skin prick testing (SPT) and serum IgE quantification, both of which are complex.
Ke‐Zhang Zhu   +4 more
wiley   +1 more source

Targeting Inflammatory Alarmin S100A9 Modulates Activation of Pro‐Inflammatory Macrophage to Protect Nasal Epithelial Cells From LPS‐Induced Epithelial–Mesenchymal Transition

open access: yesMicrobiology and Immunology, EarlyView.
ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) exhibits pronounced endotypic heterogeneity, with macrophages serving as key drivers of sustained mucosal inflammation. In this study, we identify S100A9 as a macrophage‐derived alarmin that is markedly elevated in CRSwNP tissues.
Yunxiang Ji   +5 more
wiley   +1 more source

“Super‐Responders” to Dupilumab Treatment in Patients With Primary Diffuse Chronic Rhinosinusitis With Nasal Polyps

open access: yesAllergy, EarlyView.
This study aimed to evaluate the feasibility of extending dupilumab dosing intervals in T2‐CRSwNP by assessing how many patients maintain disease control with once‐every‐12‐weeks (Q12W) dosing and comparing clinical characteristics of super‐responders and excellent responders. Tapering of dupilumab to Q12W appears feasible in super‐responding patients.
P. E. Vonk   +13 more
wiley   +1 more source

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

open access: yesAllergy, EarlyView.
ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
T. Zuberbier   +221 more
wiley   +1 more source

Relationship Between Allergy and Chronic Rhinosinusitis

open access: yes
The role of allergy in chronic rhinosinusitis is still controversial. Numerous studies have demonstrated that atopy is highly prevalent in people with chronic rhinosinusitis (CRS), and that allergies may play a part in the pathogenesis of the condition ...
Munzir, Munzir   +2 more
core  

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

open access: yesAllergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh   +7 more
wiley   +1 more source

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