Results 191 to 200 of about 37,461 (298)

Dupilumab for Chronic Rhinosinusitis with Primary Nasal Polyps: a Case Report and Literature Review

Mingrui Deng, Rao Fu, Mei Lv, Ya Feng Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of ChinaCorrespondence: Mei Lv, Department of ...
Fu R, Lv M, Feng Y, Deng M
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Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma

Allergy, EarlyView.
EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro, Ian D. Pavord, Klaus F. Rabe, Elizabeth Laws, Alexandre Jagerschmidt, Kaitlyn Gayvert, Sivan Harel, Jennifer D. Hamilton, Nikhil Amin, Lu Zhang, Heming Xing, Anissa Elfakir, Bema Coulibaly, Souâd Naimi, Sara Hamon, Paul J. Rowe, Frank Nestle, Danen M. Cunoosamy, Emanuele de Rinaldis, Leda P. Mannent   +22 more
wiley   +1 more source

Pathway-Specific Effects of Oral Corticosteroids on Eosinophilic Inflammation and Tissue Remodeling in Chronic Rhinosinusitis with Nasal Polyps. [PDF]

Int J Mol Sci
Radajewski K, Burduk P, Wierzchowska M, Antosik P, Jóźwicki J, Burduk J, Grzanka D.   +6 more
europepmc   +1 more source

Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo‐Controlled, Phase III Trial

Allergy, EarlyView.
Dupilumab significantly improved nasal polyp score, nasal congestion, olfaction, total symptom score, and disease‐specific quality of life in Chinese patients with uncontrolled CRSwNP. Incidence of treatment‐emergent adverse events was similar between dupilumab and placebo.
Mu Xian, Menglin Wang, Changqing Zhao, Lijia Wan, Yu Xu, Juan Meng, Rui Xu, Xicheng Song, Li Shi, Yucheng Yang, Yan Jiang, Yanzhen Wu, Bethany Ling, Vivian Li, Andrew P. Fontenot, Lacey R. Robinson, Neelam A. Phadke, Chengshuo Wang, Luo Zhang   +18 more
wiley   +1 more source

Early surgical intervention for orbital complications of pediatric acute rhinosinusitis: outcomes and algorithmic approach. [PDF]

BMC Pediatr
Werda M, Kharrat R, Walha O, Chaabouni MA, Mnejja M, Charfeddine I.   +5 more
europepmc   +1 more source

Remission in Global Airway Diseases: EUFOREA Consensus Paper

Allergy, EarlyView.
ABSTRACT The therapeutic goal in chronic airway diseases is shifting from symptom control to disease remission. Disease‐modifying therapies, including biologics and allergen immunotherapy, have made remission achievable in patients with severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), or allergic rhinitis (AR).
J. Christian Virchow, Xander Bertels, Vibeke Backer, Benjamin S. Bleier, Marco Caminati, Diego M. Conti, Eugenio De Corso, Mina Gaga, Valerie J. Lund, Corrado Pelaia, Anju T. Peters, Glenis K. Scadding, Martin Wagenmann, Riyad O. Al‐Lehebi, Guy G. Brusselle, Philippe Gevaert, Liam G. Heaney, Stella E. Lee, Florence Schleich, Frederik Trinkmann, Peter W. Hellings, Wytske J. Fokkens, Paola Rogliani   +22 more
wiley   +1 more source

CRSwNP in the biologics era: evaluating patient-reported quality of life outcomes. [PDF]

Front Allergy
Kang T, Qiao H, Zha Y, Wang X, Ma G, Lv W, Aodeng S.   +6 more
europepmc   +1 more source

Melioidosis in companion animals: Analysis of 45 Australian cases (24 dogs; 21 cats) from 1997 to 2025 and a brief review of the animal and human literature

Australian Veterinary Journal, EarlyView.
Objective To report 45 cases of melioidosis in dogs and cats from northern Australia and analyse trends in epidemiology, clinical presentation, pathogenesis and response to treatment over a 27‐year period. Design Retrospective and prospective analysis of clinical records.
K Lee, C Shilton, S Benedict, M Krockenberger, M Mayo, BJ Currie, R Malik   +6 more
wiley   +1 more source

Gender Differences in Emotional Burden in Chronic Rhinosinusitis: The Role of Sleep-Related Impairment. [PDF]

J Clin Med
Cantone E, Di Salle F, Ambrosio MR, Scandurra C, Bochicchio V.   +4 more
europepmc   +1 more source

The Relationship Between Allergy and Chronic Rhinosinusitis

Introduction : The role of allergy in chronic rhinosinusitis is still controversial. Many studies have shown a high prevalence of atopy in chronic rhinosinusitis patients with a possible role of allergy in the pathophysiology of chronic rhinosinusitis ...
Munzir, Munzir
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