Results 91 to 100 of about 81,443 (260)

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus

Cell Reports, 2018
Summary: Rhinovirus is a leading cause of acute respiratory infections and asthma attacks, but infections are also frequently cleared from the nasal mucosa without causing symptoms.
Valia T. Mihaylova, Yong Kong, Olga Fedorova, Lokesh Sharma, Charles S. Dela Cruz, Anna Marie Pyle, Akiko Iwasaki, Ellen F. Foxman   +7 more
doaj   +1 more source

Severe pertussis infection in infants less than 6 months of age: clinical manifestations and molecular characterization [PDF]

, 2017
We conducted a study to determine the main traits of pertussis among unimmunized infants less than 6 months of age. From August 2012 to March 2015, 141 nasopharyngeal aspirates (NPAs) were collected from infants with respiratory symptoms attending 2
Buttinelli, Gabriele, Carsetti, Rita, Concato, Carlo, Di Mattia, Greta, Fedele, Giorgio, Gesualdo, Francesco, Midulla, Fabio, Nicolai, Ambra, Stefanelli, Paola, the Pertussis Study Group,, Tozzi, Alberto E., Vacca, Paola, Villani, Alberto   +12 more
core   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections

Journal of Experimental Pharmacology, 2021
James A Coultas, 1 John Cafferkey, 2 Patrick Mallia, 1 Sebastian L Johnston 1 1National Heart and Lung Institute, Imperial College London, London, UK; 2Respiratory Medicine, St Mary’s Hospital, Imperial College Healthcare Foundation Trust, London,
Coultas JA, Cafferkey J, Mallia P, Johnston SL   +3 more
doaj  

Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression [PDF]

, 2010
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, emphysema and irreversible airflow limitation. These changes are thought to be due to oxidative stress and an imbalance of proteases and antiproteases ...
A Babusyte, A Kode, A Papi, A Sebastian, A Sydbom, AP Rogerio, AW Boots, C Kandaswami, C Tabak, CJ Vlahos, D Nowak, DC Newcomb, EH Walker, G Agullo, GA Finlay, GW Peet, HJ Park, HS Deshmukh, HS Deshmukh, I Rahman, IC Walda, IK Demedts, J Robak, JA Conquer, JC Chen, JD Hasday, JH Vernooy, JW Hwang, K Ito, K Minamoto, K Ohnishi, KF Chung, KK Meja, L Biasutto, L Larsson, L Segura-Valdez, M Comalada, M Harwood, M Ichinose, M Kasielski, M Suzuki, MK Hwang, MM Mu, N Louhelainen, O Michel, P Maestrelli, P Santus, PC Hollman, PF Mercer, PJ Jagielo, R Mahadeva, S Nanua, S Rajendrasozhan, S Shishodia, SK Biswas, SP Davies, SV Culpitt, T Shinohara, T Zheng, U Sajjan, W MacNee, Y Kaneko, Y Nakamaru, Y-T Huang   +63 more
core   +6 more sources

Exposures in Indoor Air Affecting Health

Allergy, EarlyView.
ABSTRACT Indoor air quality (IAQ) is influenced by a wide range of chemical, biological and physical agents that can negatively impact physical, immunological and mental health. Adverse health effects depend on the type and concentration of pollutants, duration of exposure, and individual susceptibility.
Maria Hartiala, Varpu Elenius, Alicia Aguado Pesquera, Silas Androulakis, Isabella Annesi‐Maesano, Artur Badyda, Sicco Brandsma, Ioanna Chatziprodromidou, Goran Gajski, Judith Garcia‐Aymerich, Chiara Giorio, Timo Hugg, Jouni J. K. Jaakkola, Sarah Koch, Pim E. G. Leonards, Angeliki Matrali, Lisa Melymuk, Natalie Mueller, Adam Muszyński, Jet Opbroek, Inês Paciência, Spyros N. Pandis, Sofya Pozdniakova, Aino K. Rantala, Sandra Rodríguez Sufuentes, Linda Schenk, Eva Sugeng, Adrià Sunyer‐Caldú, Apostolos Vantarakis, Alexander Zherebker, Ernesto Alfaro‐Moreno, Pernilla Bohlin Nizzetto, José Fermoso Dominguez, Stylianos Karatzas, Francesco Mureddu, Heidi Salonen, Nikolaos Papadopoulos, Tuomas Jartti, the IDEAL Consortium   +38 more
wiley   +1 more source

Exploring the Clinical Characteristics and Outcomes of Rhinovirus Infection in Hospitalized Children Compared with Other Respiratory Viruses

Children
Background: Acute viral respiratory tract infections constitute a significant challenge in pediatric healthcare globally, with rhinovirus representing one of the primary etiological agents.
Sigrid Covaci, Claudiu Filimon, Mihai Craiu   +2 more
doaj   +1 more source

Nasal decongestants in monotherapy for the common cold [PDF]

, 2016
Background : Many treatments for the common cold exist and are sold over-the-counter. Nevertheless, evidence on the effectiveness and safety of nasal decongestants is limited.
De Sutter, An, Deckx, Laura, Guo, Linda, Mir, Nabiel A, van Driel, Marie   +4 more
core   +2 more sources

Pathogenesis of rhinovirus infection [PDF]

Current Opinion in Virology, 2012
Since its discovery in 1956, rhinovirus (RV) has been recognized as the most important virus producing the common cold syndrome. Despite its ubiquity, little is known concerning the pathogenesis of RV infections, and some of the research in this area has led to contradictions regarding the molecular and cellular mechanisms of RV-induced illness.
Joshua L, Kennedy, Ronald B, Turner, Thomas, Braciale, Peter W, Heymann, Larry, Borish   +4 more
openaire   +2 more sources