Results 61 to 70 of about 4,436,011 (309)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury. [PDF]

PLoS ONE, 2014
The Rho/Rho-kinase pathway plays an important role in many cardiovascular diseases such as hypertension, atherosclerosis, heart failure, and myocardial infarction.
Katsunori Kitano, Soichiro Usui, Hiroshi Ootsuji, Shin-ichiro Takashima, Daisuke Kobayashi, Hisayoshi Murai, Hiroshi Furusho, Ayano Nomura, Shuichi Kaneko, Masayuki Takamura   +9 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Rho-omega mixing and the pion electromagnetic form-factor [PDF]

Physics Letters B, 1995
The suggestion of momentum dependence in the amplitude for rho-omega mixing has generated concern over related implications for vector meson dominance and the photon-rho coupling. We discuss two established representations of vector meson dominance and show that one of these is completely consistent with such a coupling.
O'Connell, H., Pearce, B., Thomas, A., Williams, A.   +3 more
openaire   +3 more sources

Avaliação, in vivo e in vitro, da reatividade vascular renal à vasopressina em ratos endotoxêmicos: importância da via Rho-A/Rho-quinase [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaSepse é uma infecção local, acompanhada de uma resposta inflamatória sistêmica e vinculada à elevada incidência e ...
Guarido, Karla Lorena
core  

Rho GTPases in Glioblastoma Mechanobiology [PDF]

, 2020
Brain tumors are a source of morbidity and mortality worldwide, especially in children and young adults. Due to the high rates of inherently disabling effects (such as personality changes, visual disturbances, and poor coordination), many patients with ...
Xu, Jing
core  

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. [PDF]

, 2012
Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell ...
Valderrama, F, Riou, P, Muschel, Ruth, Susan Cox, Garg, Ritu, Vega, FM, Im, Jae Hong, Im, JH, Valderrama, Ferran, Ritu Garg, Muschel, Ruth J, Ridley, Anne J, Garg, R, Cox, Susan, Barbara Borda d’Agua, Cox, S, Vega, Francisco M., d'Agua, Barbara Borda, Reymond, N, Nicolas Reymond, Philippe Riou, Borda d'Agua, Barbara, Ferran Valderrama, Reymond, Nicolas, Jae Hong Im, Riou, Philippe, Muschel, Ruth J., Borda d'Agua, B, Ridley, AJ, Francisco M. Vega, Muschel, RJ, Anne J. Ridley, Ridley, Anne J., Vega, Francisco M, Ruth J. Muschel   +34 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection

Frontiers in Immunology, 2019
Cognitive dysfunction persists in 30–50% of chronically HIV-infected individuals despite combination antiretroviral therapy (ART). Although monocytes are implicated in poor cognitive performance, distinct biological mechanisms associated with cognitive ...
Michelle L. D'Antoni, Michelle L. D'Antoni, Kalpana J. Kallianpur, Kalpana J. Kallianpur, Thomas A. Premeaux, Michael J. Corley, Tsuyoshi Fujita, Elizabeth I. Laws, Debra Ogata-Arakaki, Dominic C. Chow, Vedbar S. Khadka, Cecilia M. Shikuma, Lishomwa C. Ndhlovu, Lishomwa C. Ndhlovu   +13 more
doaj   +1 more source

ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model

Scientific Reports, 2021
Retinitis Pigmentosa (RP) is a blinding disease that arises from loss of rods and subsequently cones. The P23H rhodopsin knock-in (P23H-KI) mouse develops retinal degeneration that mirrors RP phenotype in patients carrying the orthologous variant ...
Eun-Jin Lee, Priscilla Chan, Leon Chea, Kyle Kim, Randal J. Kaufman, Jonathan H. Lin   +5 more
doaj   +1 more source