Results 51 to 60 of about 4,436,011 (309)

Analysis of Rho GTPase signalling pathways regulating epithelial morphogenesis [PDF]

, 2010
Rho GTPases are molecular switches controlling many aspects of cell behaviour, including cell cycle progression, cell division, migration and morphology. The activity of Rho proteins is regulated by conformational changes induced by binding of guanine
Wallace, S.
core  

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Functional Significance of the Rho/Rho-Kinase Pathway in Human Erythrocytes

Turkish Journal of Hematology, 2014
OBJECTIVE: Erythrocyte deformability, which can be influenced by various intracellular signaling mechanisms, such as nitric oxide, cAMP, cGMP, and protein kinases, is the most important physiological factor providing the blood flow in microcirculation ...
R. Nalan Tiftik, Oğuz K. Başkurt, Seval Kul, Kansu Büyükafşar   +3 more
doaj   +1 more source

Studying QCD factorizations in exclusive gamma* gamma* -> rho^0_L rho^0_L

, 2007
invited talk presented at EDS07 11 ...
Wallon, S., Pire, B., Segond, M., Szymanowski, L.   +3 more
openaire   +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Relation between Variances of 3D Density and Its 2D Column Density Revisited

The Astrophysical Journal
We revisit the relation between the variance of three-dimensional (3D) density ( ${\sigma }_{\rho }^{2}$ ) and that of the projected two-dimensional (2D) column density ( ${\sigma }_{{\rm{\Sigma }}}^{2}$ ) in turbulent media, which is of great importance
Heesun Yoon, Jungyeon Cho
doaj   +1 more source

Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death

Nature Communications, 2017
The transcription termination factor Rho is essential for growth in some bacteria but not in others. Here, Botellaet al. show that Rho inactivation causes extensive pervasive transcription and loss of viability of the pathogen Mycobacterium tuberculosis ...
Laure Botella, Julien Vaubourgeix, Jonathan Livny, Dirk Schnappinger   +3 more
doaj   +1 more source

Inflammatory markers in acute myocardial infarction and the correlation with the severity of coronary heart disease

Annals of Medicine, 2021
Introduction The inflammatory hypothesis of atherosclerosis is appealing in acute coronary syndromes, but the dynamics and precise role are not established.Objectives The study investigates the levels of C reactive protein (CRP), interleukin 1β (IL-1β ...
Nicoleta Oprescu, Miruna Mihaela Micheu, Alexandru Scafa-Udriste, Nicoleta-Monica Popa-Fotea, Maria Dorobantu   +4 more
doaj   +1 more source

Generation and evaluation of a transgenic zebrafish for tissue-specific expression of a dominant-negative Rho-associated protein kinase-2 [PDF]

, 2020
The Ras homologous (Rho) proteins are a family of small GTPases, which regulate the cytoskeleton and are related to stress fibers and focal adhesion. The Rho-associated protein kinases (ROCK) constitute part of the Rho effectors that regulate cell shape ...
Wang, Zi, Hondo, Eiichi, Iida, Atsuo, Sehara-Fujisawa, Atsuko   +3 more
core   +1 more source