Results 141 to 150 of about 82,160 (288)

Optimal experimental design in an EGFR signaling and down-regulation model [PDF]

arXiv, 2006
We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho ...
arxiv  

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

Journal of Biological Chemistry, 1994
GTP-binding proteins of the Rho family are maintained as cytosolic complexes with RhoGDI in resting cells, but are released and translocate to the membrane during the course of cell activation. Membrane association of Rac/Rho/CDC42 was specifically induced by GTP analogs and required a heat- and trypsin-labile membrane component.
Gary M. Bokoch, Tsung-Hsien Chuang, Benjamin P. Bohl   +2 more
openaire   +3 more sources

The Human‐Specific miR‐6762‐5p Is an Activator of RhoA GTPase Enhancing Shigella flexneri Intercellular Spreading

Molecular Microbiology, Volume 123, Issue 5, Page 420-432, May 2025.
Proposed model in which human miR‐6762‐5p expression activates RhoA to promote Shigella flexneri dissemination: During the late phase of infection, miR‐6762‐5p is expressed from its host gene TPCN1. This leads to RhoA activation and thus stress fiber formation.
Caroline Reisacher, Estelle Saifi, Elisabeth Ageron, Robert Theodor Mallmann, Norbert Klugbauer, David Skurnik, Laurence Arbibe   +6 more
wiley   +1 more source

EGF‐Induced Macropinocytosis Promotes NAV1‐Dependent Internalization of Occludin in Keratinocytes

The FASEB Journal, Volume 39, Issue 8, 30 April 2025.
This graphical abstract illustrates how epidermal growth factor (EGF) stimulates macropinocytosis in keratinocytes, leading to the internalization of occludin, a key tight junction protein. NAV1 is identified as a critical mediator of this process, modulating macropinocytosis via the Rho family of GTPases.
Haruka Taira, Lixin Li, Asumi Koyama, Rino Toyoshima, Toyoki Yamamoto, Yukiko Ito, Eiki Sugimoto, Yuka Mizuno, Kentaro Awaji, Shinichi Sato, Sayaka Shibata   +10 more
wiley   +1 more source

Vav family exchange factors: Potential regulator in atherosclerosis

Biochemistry and Biophysics Reports
The Vav family of guanosine nucleotide exchange factors (GEFs) regulates the phosphorylation of tyrosinase, influencing various physiological and pathological processes by modulating the binding of Rho GTPases to GDP/GTP.
Yu Zhang, Yongwei Ren, Tao Zhou, Zhengtao Qian, Zhengyang Bao   +4 more
doaj  

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

Journal of Biological Chemistry, 1993
The small GTP-binding protein Rho regulates the assembly of actin stress fibers and focal adhesions in cells responding to growth factors. ADP-ribosylation of Rho by C3 transferase blocks this function; however, an enzymatic target for Rho has not yet been defined.
Jin Zhang, A. Hall, S. Dillon, Larry A. Feig, W. G. King, Susan E. Rittenhouse   +5 more
openaire   +3 more sources

Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks? [PDF]

arXiv, 2006
In protein-protein interaction networks certain topological properties appear to be recurrent: networks maps are considered scale-free. It is possible that this topology is reflected in the protein structure. In this paper we investigate the role of protein disorder in the network topology.
arxiv  

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. [PDF]

, 2017
Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease.
Aplin, Andrew E., Benovic, Jeffrey L., Chua, Vivian, Lapadula, Dominic, Randolph, Clinita, Wedegaertner, Philip B.   +5 more
core   +1 more source

Efficient Finite Difference Method for Computing Sensitivities of Biochemical Reactions

, 2018
Sensitivity analysis of biochemical reactions aims at quantifying the dependence of the reaction dynamics on the reaction rates. The computation of the parameter sensitivities, however, poses many computational challenges when taking stochastic noise ...
Priami, Corrado, Thanh, Vo Hong, Zunino, Roberto   +2 more
core   +1 more source

Refining the Protein-Protein Interactome using Gene Expression Data [PDF]

arXiv, 2010
Proteins interact with other proteins within biological pathways, forming connected subgraphs in the protein-protein interactome (PPI). Proteins are often involved in multiple biological pathways which complicates interpretation of interactions between proteins.
arxiv