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Rho GTP-Binding Proteins as Targets for Microbial Pathogens
1999Conceptual approaches in microbial pathogenesis studies have evolved quickly in the last 10 years, due to the development of cell biology. The merging of cell biology and microbial pathogenesis has been called cellular microbiology (Cossart et al. 1996), definitively sealing this seminal association.
P, Boquet +2 more
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Cellular responses regulated by rho-related small GTP-binding proteins
Philosophical Transactions of the Royal Society B: Biological Sciences, 1993Abstract Rho-related proteins are members of the ras superfamily of small GTP-binding proteins. Their function in fibroblasts has been analysed using microinjection of living cells. Rho appears to link plasma membrane receptors to the assembly of focal adhesions and actin stress fibres.
H F Paterson +2 more
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The International Journal of Biochemistry & Cell Biology, 1997
RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP-bound form. Their activity in cells is regulated by exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors.
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RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP-bound form. Their activity in cells is regulated by exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors.
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Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins
Trends in Cell Biology, 1995Rho proteins, which are involved in receptor-mediated regulation of the actin cytoskeleton, are substrates for ADP-ribosylation by Clostridium botulinum C3 toxins. Recently, it was shown that Rho and other members of the Rho subfamily of low-molecular-mass GTP-binding proteins are glucosylated by C. difficile toxins A and B.
Klaus Aktories, Ingo Just
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Tissue-specific variations in the expression and regulation of the small GTP-binding protein Rho
Biochimica Et Biophysica Acta - Molecular Cell Research, 1994Rho proteins are involved in the regulation of the assembly of the microfilamental cellular network and are known to be specific substrates for the ADP-ribosyltransferase C3 from Clostridium botulinum. Here, we studied the distribution of Rho and Rho-regulating proteins in extracts from various rabbit tissues.
Gerhard Fritz, Ingo Just
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Current Opinion in Cell Biology, 1998
Accumulating evidence indicates that Rho family small GTP-binding proteins regulate reorganization of the actin cytoskeleton. There are members of the Rho family in the budding yeast Saccharomyces cerevisiae, in which powerful molecular genetical approaches are applicable.
Kazuma Tanaka, Yoshimi Takai
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Accumulating evidence indicates that Rho family small GTP-binding proteins regulate reorganization of the actin cytoskeleton. There are members of the Rho family in the budding yeast Saccharomyces cerevisiae, in which powerful molecular genetical approaches are applicable.
Kazuma Tanaka, Yoshimi Takai
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Rho-GTP Binding Proteins in Yersinia Target Cell Interaction
2004Among the more than 10 Yersinia species known three are pathogenic for humans: (i) Y. pestis is the causative agent of plaque, (ii) Y. pseudotuberculosis and (iii) Y. enterocolitica are enteropathogenic. The infection process of enteropathogenic yersiniae involves invasive as well as antiphagocytic and other immunomodulatory components.
Aepfelbacher, Martin +3 more
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Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins
Journal of Microscopy, 2008SummaryThe Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
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Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI [PDF]
Cell, 2000 The RhoGDI proteins serve as key multifunctional regulators of Rho family GTP-binding proteins. The 2.6 A X-ray crystallographic structure of the Cdc42/RhoGDI complex reveals two important sites of interaction between GDI and Cdc42. First, the amino-terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the ...
Nicolas Nassar, Richard A Cerione
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Signal transduction through the GTP-binding proteins Rac and Rho
Journal of Cell Science, 1994ABSTRACT Actin reorganization is an early response to many extra- cellular factors. In Swiss 3T3 fibroblasts, the Ras-related GTP-binding proteins Rho and Rac act as key signal trans- ducers in these responses: Rho is required for growth factor-induced formation of stress fibres and focal adhesions, whereas membrane ruffling is regulated
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