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The International Journal of Biochemistry & Cell Biology, 1997
RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP-bound form. Their activity in cells is regulated by exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors.
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RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP-bound form. Their activity in cells is regulated by exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors.
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Signal transduction through the GTP-binding proteins Rac and Rho
Journal of Cell Science, 1994ABSTRACT Actin reorganization is an early response to many extra- cellular factors. In Swiss 3T3 fibroblasts, the Ras-related GTP-binding proteins Rho and Rac act as key signal trans- ducers in these responses: Rho is required for growth factor-induced formation of stress fibres and focal adhesions, whereas membrane ruffling is regulated
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Characterization of a Monoclonal Antibody Specific for the Ras-Related GTP-Binding Protein Rho A
Biochemical and Biophysical Research Communications, 1993The Rho family of small GTP-binding proteins is one of the three subgroups which, together with the Ras and Rab families, constitute the Ras-related superfamily. The Rho subgroup contains at least seven highly homologous members including 4 Rho proteins (RhoA, RhoC, RhoB, and RhoG), the Rac1 and Rac2 proteins, and CDC42Hs, which are involved in various
P, Lang +6 more
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Activation of the small GTP-binding proteins rho and rac by growth factor receptors
Journal of Cell Science, 1995ABSTRACT The small GTP-binding proteins, rho and rac, control signal transduction pathways that link growth factor receptors to the activation of actin polymerization. In Swiss 3T3 cells, rho proteins mediate the lysophosphatidic acid and bombesin-induced formation of focal adhesions and actin stress fibres, whilst rac proteins are ...
C D, Nobes +3 more
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Intrasynaptosomal distribution of the ras, rho and smg-25A GTP-binding proteins in bovine brain
Molecular Brain Research, 1989We have purified to near homogeneity and characterized three small molecular weight (Mr) GTP-binding proteins, the c-Ki-ras protein (c-Ki-ras p21), the rho protein (rho p20) and a novel smg-25A protein (smg p25A), from bovine brain crude membranes.
S, Kim +3 more
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Augmentation of human leukemic cell invasion by activation of a small GTP-binding protein Rho
Experimental Hematology, 2000The functions of a small GTP-binding protein, Rho, in human leukemic cell invasion was investigated in vivo and in vitro.Human leukemic KM3 and Reh cells (derived from B-cell-type common acute lymphoid leukemias) were inoculated into severe combined immundeficiency (SCID) mice.
S, Fukushima +4 more
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Regulation of cytoskeletal functions by Rho small GTP-binding proteins in normal and cancer cells
Canadian Journal of Physiology and Pharmacology, 1996The actin cytoskeleton is involved in numerous cellular functions such as cell motility, mitogenesis, morphology, muscle contraction, cytokinesis, and establishment of cell polarity. The members of the Rho subfamily of small GTP-binding proteins emerge as key regulators of cytokeleton organization.
D, Boivin, D, Bilodeau, R, Béliveau
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Signaling Pathways Controlled by Rho Family GTP-Binding Proteins
2000The current Rho family picture contains 11 mammalian members, which can be subdivided into five groups on the basis of sequence and functional differences: (1) RhoA, RhoB, and RhoC; (2) Rac1, Rac2, and RhoG; (3) Cdc42 and TC10; (4) RhoD; and (5) RhoE and TTF (1,2).
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Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins.
Current Opinion in Cell Biology, 1996J. T. Parsons
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