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Rho GTP-Binding Proteins as Targets for Microbial Pathogens
1999Conceptual approaches in microbial pathogenesis studies have evolved quickly in the last 10 years, due to the development of cell biology. The merging of cell biology and microbial pathogenesis has been called cellular microbiology (Cossart et al. 1996), definitively sealing this seminal association.
Philippe J. Sansonetti +2 more
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The International Journal of Biochemistry & Cell Biology, 1997
RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP-bound form. Their activity in cells is regulated by exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors.
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RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP-bound form. Their activity in cells is regulated by exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors.
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Rho-GTP Binding Proteins in Yersinia Target Cell Interaction
2004Among the more than 10 Yersinia species known three are pathogenic for humans: (i) Y. pestis is the causative agent of plaque, (ii) Y. pseudotuberculosis and (iii) Y. enterocolitica are enteropathogenic. The infection process of enteropathogenic yersiniae involves invasive as well as antiphagocytic and other immunomodulatory components.
Aepfelbacher, Martin +3 more
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Rho family small GTP-binding proteins in growth cone signalling
Current Opinion in Neurobiology, 1997Rho family GTP-binding proteins regulate various aspects of the actin cytoskeleton in a wide variety of organisms. Recent evidence suggests that they may also be important components of the signalling pathways that link the reception of extracellular cues to the regulation of the cytoskeleton in neuronal growth cones.
Lily Yeh Jan, Liqun Luo, Yuh Nung Jan
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Cellular responses regulated by rho-related small GTP-binding proteins
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993Rho-related proteins are members of the ras superfamily of small GTP-binding proteins. Their function in fibroblasts has been analysed using microinjection of living cells. Rho appears to link plasma membrane receptors to the assembly of focal adhesions and actin stress fibres.
Peter Adamson +3 more
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Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins
Journal of Microscopy, 2008SummaryThe Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
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Characterization of a Monoclonal Antibody Specific for the Ras-Related GTP-Binding Protein Rho A
Biochemical and Biophysical Research Communications, 1993The Rho family of small GTP-binding proteins is one of the three subgroups which, together with the Ras and Rab families, constitute the Ras-related superfamily. The Rho subgroup contains at least seven highly homologous members including 4 Rho proteins (RhoA, RhoC, RhoB, and RhoG), the Rac1 and Rac2 proteins, and CDC42Hs, which are involved in various
J.M. Thiberge +6 more
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Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1997The endothelial cytoskeleton is important for the regulation of endothelial barrier function. Small GTP-binding Rho proteins play a central role in the organization of the microfilament system. Clostridium difficile toxin B (TcdB) inactivates Rho proteins by glucosylation at Thr-37.
Hippenstiel, Stefan +7 more
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Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins
Trends in Cell Biology, 1995Rho proteins, which are involved in receptor-mediated regulation of the actin cytoskeleton, are substrates for ADP-ribosylation by Clostridium botulinum C3 toxins. Recently, it was shown that Rho and other members of the Rho subfamily of low-molecular-mass GTP-binding proteins are glucosylated by C. difficile toxins A and B.
Ingo Just, Klaus Aktories
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Tissue-specific variations in the expression and regulation of the small GTP-binding protein Rho
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1994Rho proteins are involved in the regulation of the assembly of the microfilamental cellular network and are known to be specific substrates for the ADP-ribosyltransferase C3 from Clostridium botulinum. Here, we studied the distribution of Rho and Rho-regulating proteins in extracts from various rabbit tissues.
Ingo Just, Paul Lang, Gerhard Fritz
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