Results 151 to 160 of about 123,069 (394)
Nature Communications, 2017 Blood platelets are produced by large bone marrow (BM) precursor cells, megakaryocytes (MKs), which extend cytoplasmic protrusions (proplatelets) into BM sinusoids.
Sebastian Dütting +25 more
semanticscholar +1 more source
“Time Is Brain” – for Cell Therapies
Advanced Science, EarlyView.The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin +4 more
wiley +1 more source
AMPK alpha 1-induced RhoA phosphorylation mediates vasoprotective effect of estradiol [PDF]
, 2011 OBJECTIVE: Estradiol (E2) mediates numerous beneficial effects assigned to estrogens, but whereas mechanisms have been described at the endothelial level, direct effects on vascular smooth muscle cells (VSMC) are poorly documented.
A. Rousselle +7 more
core +4 more sources
Investigative Ophthalmology and Visual Science, 2018 Purpose Biomechanical properties changes and α-smooth muscle actin (α-SMA) overexpression are involved in myopia scleral remodeling. However, interactions between altered tissue biomechanics and cellular signaling that sustain scleral remodeling have not
Ying Yuan +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng +20 more
wiley +1 more source
A sulfated carbohydrate epitope inhibits axon regeneration after injury [PDF]
, 2012 Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the structure-activity relationships ...
Brown, Joshua M. +14 more
core +2 more sources
Scientific Reports, 2017 Traumatic brain injury (TBI) causes extensive neural damage, often resulting in long-term cognitive impairments. Unfortunately, effective treatments for TBI remain elusive.
Shalaka Mulherkar +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang +5 more
wiley +1 more source
RhoA, encoding a Rho GTPase, is associated with smoking initiation [PDF]
, 2006 Xing Chen +7 more
openalex +1 more source
Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement [PDF]
, 2000 G2A is an orphan G protein-coupled receptor (GPCR), expressed predominantly in T and B cells and homologous to a small group of GPCRs of unknown function expressed in lymphoid tissues.
Feramisco, Jamison D. +6 more
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