Results 171 to 180 of about 99,117 (203)

P53 in RhoA regulation

Cytoskeleton, 2020
AbstractRecent evidence suggest that dysregulation of the tumor suppressor P53, in combination with disharmonious activities of the small GTPase RhoA, may lead to irreversible progression of human disease. The purpose of the present study is to communicate the most recent information regarding the highly interrelated P53/RhoA network.
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RhoA and resistance artery remodeling

American Journal of Physiology-Heart and Circulatory Physiology, 2005
Resistance arteries are able to adapt to physiological and pathophysiological stimuli to maintain adequate perfusion according to the metabolic demand of the tissue. Although vasomotor control allows rapid adaptation of lumen diameter, vascular remodeling constitutes an active process that occurs in response to long-term alterations of hemodynamic ...
Gervaise, Loirand, Malvyne, Rolli-Derkinderen, Pierre, Pacaud   +2 more
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Inhibition of RhoA by p120 catenin

Nature Cell Biology, 2000
RhoA organizes actin stress fibres and is necessary for cell transformation by oncogenes such as src and ras. Moreover, RhoA is implicated in cadherin clustering during the formation of adherens junctions. The catenin p120 has also been implicated in cadherin clustering through an unknown mechanism.
P Z, Anastasiadis, S Y, Moon, M A, Thoreson, D J, Mariner, H C, Crawford, Y, Zheng, A B, Reynolds   +6 more
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Nuanced junctional RhoA activity

Nature Cell Biology, 2012
RhoA signalling controls many diverse cellular processes, and thus discovering the mechanisms that determine its specific outcomes is a tantalizing challenge. A previously uncharacterized regulatory module operates selectively at the zonula adherens of epithelial cell junctions, in which positive and negative RhoA regulators are coordinated to fine ...
Swapnil S. Kher, Rebecca A. Worthylake
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RhoA inactivation enhances endothelial barrier function

American Journal of Physiology-Cell Physiology, 1999
The modulation of endothelial barrier function is thought to be a function of contractile tension mediated by the cell cytoskeleton, which consists of actomyosin stress fibers (SF) linked to focal adhesions (FA). We tested this hypothesis by dissociating SF/FA with Clostridium botulinum exoenzyme C3 transferase (C3), an inhibitor of the small GTP ...
J M, Carbajal, R C, Schaeffer
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Activated RHOA and peripheral axon regeneration

Experimental Neurology, 2008
The regeneration of adult peripheral neurons after transection is slow, incomplete and encumbered by severe barriers to proper regrowth. The role of RHOA GTPase has not been examined in this context. We examined the expression, activity and functional role of RHOA GTPase and its ROK effector, inhibitors of regeneration, during peripheral axon outgrowth.
C, Cheng, C A, Webber, J, Wang, Y, Xu, J A, Martinez, W Q, Liu, D, McDonald, G F, Guo, M D, Nguyen, D W, Zochodne   +9 more
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Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation

Molecular and Cellular Neuroscience, 2005
Relatively little is known about the relationship between cellular lipid composition and the ability of neuroblasts to elaborate axonal and dendritic processes. We have studied the role of cholesterol and non-sterol isoprenoids during neurite outgrowth in PC-12 cells using inhibitors of cholesterol biosynthesis that act at different points in the ...
Carlos, Fernández-Hernando, Yajaira, Suárez, Miguel A, Lasunción   +2 more
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RhoA

1995
Abstract Rho sequences were originally isolated from an Aplysia cDNA library and used to identify three distinct, but highly homologous human sequences (Madaule and Axel 1985). The complete sequence of one of these, RhoA (originally called clone 12) (Yeramian et al. 1987), is shown in Fig. 1. The GenBank accession number is X05026.
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Inactivation of RhoA for Hypertension Treatment Through the TRPV4–RhoA–RhoGDI1 Axis

Circulation
BACKGROUND: The RhoA (Ras homolog family member A) signaling pathway is pivotal in regulating vascular smooth muscle cells (VSMCs) function and blood pressure homeostasis. Current inhibitors of the RhoA signaling pathway are limited in hypertension treatment, suffering from poor efficacy, insufficient specificity, and ...
Jiawen Wang, Zhen Yuan, Na Yu, Qian Jiao, Honglei Zhou, Wenjie Liao, Jiwei Shan, Shanshan Ruan, Yi Zhao, Ya Mo, Luyao Qi, Tiejun Li, Jianjun Fu, Bowen Ke, Yufang Xu, Xuhong Qian, Jian Zhang, Zhenjiang Zhao, Shiliang Li, Rui Wang, Honglin Li   +20 more
exaly   +2 more sources

Targeting by myosin phosphatase‐RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase

Journal of Cellular Biochemistry, 2007
AbstractVascular smooth muscle cell contractile state is the primary determinant of blood vessel tone. Vascular smooth muscle cell contractility is directly related to the phosphorylation of myosin light chains (MLCs), which in turn is tightly regulated by the opposing activities of myosin light chain kinase (MLCK) and myosin phosphatase.
Nadeene, Riddick, Ken-Ichi, Ohtani, Howard K, Surks   +2 more
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