Results 211 to 220 of about 123,069 (394)
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Environmental Elasticity Regulates Cell-type Specific RHOA Signaling and Neuritogenesis of Human Neurons [PDF]
, 2019 Robert H. Nichol +4 more
openalex +1 more source
A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto +12 more
wiley +1 more source
Permissive role of protein kinase Cα but not protein kinase Cδ in sphingosine 1‐phosphate‐induced RhoA activation in C2C12 myoblasts [PDF]
, 2000 Elisabetta Meacci +4 more
openalex +1 more source
From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma
Cancer Science, EarlyView.ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley +1 more source
Cellular Redistribution of PKCα, rhoA, and ROKα Following Smooth Muscle Agonist Stimulation
, 1999 Michael J. Taggart +2 more
openalex +2 more sources
Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects [PDF]
, 2015 Gisele Espinha +3 more
openalex +1 more source
Cancer Science, EarlyView.Cancer‐specific antihuman podoplanin antibody chLpMab‐2f exerted antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against pleural mesothelioma (PM) cell lines. Additionally, chLpMab‐2f inhibited tumor progression in mice with subcutaneously and intrathoracically transplanted human PM cells.
Aito Yoshida +15 more
wiley +1 more source