Results 241 to 250 of about 123,069 (394)

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether. [PDF]

Nat Commun
Yang Z, Nakajima S, Chen H, Chakrabarty Y, Feng H, Chan DC.   +5 more
europepmc   +1 more source

High Sensitivity Quantitative Allele Specific RHOA G17V PCR for Diagnosis, Staging and Minimal Residual Disease Assessment in Angioimmunoblastic T-Cell Lymphoma

, 2018
Yulia Sidorova, Н. Г. Чернова, А. М. Ковригина, М. Н. Синицына, Т. Н. Моисеева, L.S. Al- Radi, M.Yu Aleksenko, О А Глинщикова, Svetlana Smirnova, Natalya Ryzhikova, Elena Nikulina, E. I. Zakharko, E. B. Rybkina, В. Н. Двирнык, Andrey Sudarikov   +14 more
openalex   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

VIRMA/IGF2BP3-mediated ANLN upregulation promotes intrahepatic cholangiocarcinoma growth by forming a positive feedback loop with RhoA/YAP1/TEAD1 signaling pathway. [PDF]

Cell Death Dis
Zhang J, Huang N, Gao LR, Guo A, Deng H, Wang L, Liu M.   +6 more
europepmc   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Protocol to identify mechanosensitive nuclear proteins using tunable actomyosin contractility and proximity biotinylation in mammalian cells. [PDF]

STAR Protoc
Tseng PL, Sun W, Li J, Collins MO, Erdmann KS.   +4 more
europepmc   +1 more source

Neohesperidin alleviates the inhibitory effect of bisphenol A on the myogenic differentiation of umbilical cord mesenchymal stem cells via the IGF1R/AKT1/RHOA signaling pathway

Jie Yang, Sen Qin, Nannan Sun, Cai Yang, Junling Li, Z. Zhai, Jie An, Hejie Wang, Rong Du, Jian Qin   +9 more
openalex   +1 more source

Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

, 2013
Amine Belaïd, Michaël Cerezo, Abderrahman Chargui, Elisabeth Corcelle–Termeau, Florence Pédeutour, Sandy Giuliano, Marius Ilié, Isabelle Rubera, Michel Tauc, Sophie Barale, Corine Bertolotto, Patrick Brest, Valérie Vouret‐Craviari, Daniel J. Klionsky, Georges F. Carle, Paul Hofman, Baharia Mograbi   +16 more
openalex   +1 more source

The RhoA guanine exchange factor ABR: a glucose‐sensitive mediator of actin reorganization in feto‐placental arterial endothelial cells altered by gestational diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic, Boris Novakovic, Barbara Leopold‐Posch, Magdalena Mühlberger, Denise Hoch, Jelena Lögl, Eva M. Bernhart, Richard Saffery, Gernot Desoye, Ursula Hiden   +9 more
wiley   +1 more source