Results 251 to 260 of about 104,378 (298)

Hydrogel Viscoelasticity Modulates Cell Nascent Extracellular Matrix Deposition

Macromolecular Rapid Communications, Volume 46, Issue 21, November 6, 2025.
In this study, interpenetrating polymer network hydrogels with tunable viscoelastic properties were developed to study the mechanical regulation of nascent extracellular matrix (nECM) deposition. Cells cultured on high‐viscosity (high tanδ) hydrogels deposited more nECM and increased hydrogel remodeling independent of cellular contraction forces. These
Matthew L. Tan, Avinava Roy, Eleanor M. Plaster, Haguy Wolfenson, Adam Abraham, Claudia Loebel   +5 more
wiley   +1 more source

Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections. [PDF]

Front Immunol
Bravo-Silva JJ, Jimenez-Camacho R, Benítez-Vega ML, Hernández-Castillo J, Cordero-Rivera CD, Farfan-Morales CN, Pérez-García M, Cruz R, Del Ángel RM.   +8 more
europepmc   +1 more source

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
This review offers a comprehensive overview of the mechanisms by which circadian rhythms modulate tissue homeostasis, alongside the associations between circadian disturbances and circadian rhythm‐related diseases. Furthermore, we offer insights into circadian rhythm‐regulating therapies, which may contribute to the development of novel strategies for ...
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin   +13 more
wiley   +1 more source

Total Flavones of <i>Rhododendron</i> Protect Against Ischemic Cerebral Injury by Regulating the Phosphorylation of the RhoA-ROCK₂ Pathway via Endothelial-Derived H₂S. [PDF]

Curr Issues Mol Biol
Sun X, Zhang X, Li Y, Wen J, Chen Z, Chen S.   +5 more
europepmc   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, Volume 35, Issue 6, November 2025.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

Emerging role of long non‑coding RNAs in the Rho/ROCK signaling pathway in tumor metastasis (Review). [PDF]

Int J Mol Med
Nie H, Yang X, Chen Q, He X, Han Y, He Q, Ou C.   +6 more
europepmc   +1 more source

Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin

, 2013
Amanda L. Neisch, Étienne Formstecher, Richard G. Fehon   +2 more
openalex   +2 more sources

ROS‐Driven PKCζ Signaling as a Widely Involved Mechanism for Cancer Cell Motility and Metastasis

Cancer Science, Volume 116, Issue 11, Page 3027-3039, November 2025.
This study reveals that the enhancement of cancer cell motility by diverse bioactive molecules—including growth factors, hormones, and tissue factors—is mediated through a common intracellular mechanism involving reactive oxygen species (ROS) and the PKCζ/Rho GTPase signaling pathway.
Yasushi Sato, Maki Tanaka, Naoko Kitamura, Naoko Araki, Wataru Kurata, Akiko Sasaki, Yukimi Seo, Kageaki Kuribayashi, Shuzo Kobayashi, Yoshiro Niitsu   +9 more
wiley   +1 more source

Case Report: Association of Ocular Colobomas With a Novel Missense Variant in CDC42, a Member of the Rho Family of Small GTPases

Clinical Genetics, Volume 108, Issue 5, Page 589-593, November 2025.
We report a 2‐year‐old male with clinical features of Takenouchi‐Kosaki syndrome, bilateral colobomas, and a de novo, likely pathogenic missense variant in CDC42. Supportive evidence includes a Cdc42 conditional knock‐out mouse model with colobomas.
Diana Brightman, Nawaal Shinwari, Aleksey Porollo, Eniolami O. Dosunmu, Ehsan Ullah, Bin Guan, Robert B. Hufnagel, Brian P. Brooks, Delphine Blain, Sabine Fuhrmann, Brittany Simpson, Anne M. Slavotinek   +11 more
wiley   +1 more source

Host RhoA Signaling Controls Filamentous vs. Spherical Morphogenesis and Cell-to-Cell Spread of RSV via Lipid Raft Localization: Host-Directed Antiviral Target. [PDF]

Microorganisms
Pastey MK, McCurdy LH, Graham BS.
europepmc   +1 more source