Results 311 to 320 of about 123,069 (394)

Proximity-based proteomics (BioID) uncovers the Rho GTPase interactome in kidney podocytes. [PDF]

Front Cell Dev Biol
Ibrahim S, Matsuda J, Nurcombe ZW, Boulais J, Aoudjit L, Foxman E, Kazan C, Suzuki S, Leclerc S, Shimada N, Kitzler T, Coté JF, Takano T.   +12 more
europepmc   +1 more source

Fabp5 Is the Key Regulator Mediating γ‐CEHC Differentiation in Osteoblasts and Osteoclasts

BioFactors, Volume 52, Issue 1, January/February 2026.
γ‐CEHC, as a natural Fabp5 inhibitor, ameliorates the osteoporotic microenvironment through a triple‐action mechanism—targeting Fabp5 inhibition → modulating macrophage polarization → balancing bone metabolism—highlighting its translational medical value.
Cheng Cheng, Rong Chen, Minjuan Li, Shuai Lu, Xinping Li, Gengli Cui, Hailing Chen, Xieyuan Jiang   +7 more
wiley   +1 more source

KSR1 is a scaffold for the Hippo signaling pathway. [PDF]

Commun Biol
Sayedyahossein S, Babu Sait MR, Li Z, Banerjee R, Tran A, Thines L, Karimi M, Bahmani M, Mishan N, Borzou P, Hassan SA, Sacks DB.   +11 more
europepmc   +1 more source

Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription

, 2014
Dean P. Staus, Laura Weise-Cross, Kevin Mangum, Matt D. Medlin, Lee Mangiante, Joan M. Taylor, Christopher P. Mack   +6 more
openalex   +1 more source

Trichinella spiralis serine protease mediates larval invasion of gut epithelium via binding to CK8 and activating RhoA/ROCK1 pathway. [PDF]

PLoS Negl Trop Dis
Zheng WW, Zhang XZ, Cong PK, Zhang R, Long SR, Zhang X, Liu RD, Wang ZQ, Cui J.   +8 more
europepmc   +1 more source

The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics

Brain and Behavior, Volume 16, Issue 1, January 2026.
First, we evaluated of differences in sphingolipid metabolism using peripheral blood samples from IS patients and healthy controls. Then, we identify the hub genes linking sphingolipid metabolism and neuronal death via modular analysis of protein‐protein interaction networks.
Zhong‐can Chen, Fang‐biao Xu, Sen Hu, Qiang Cui, Hugo Andrade Barazarte, Jing Zhang, Li‐na Suo, Jian‐jun Gu, Jiang‐yu Xue   +8 more
wiley   +1 more source

Mechanometabolism of cell adhesion: Vinculin regulates bioenergetics via RhoA-ROCK. [PDF]

J Cell Biol
Fabiano ED, Techasiriwan EP, Sabo LN, Seluga N, Hoffman BD, Reinhart-King CA.   +5 more
europepmc   +1 more source

TTBK2‐Driven Ciliogenesis Is Required for Intrinsic Neuronal Regeneration After Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
TTBK2‐dependent ciliogenesis is required for intrinsic neuronal regeneration after spinal cord injury. Loss of TTBK2 disrupts primary cilium integrity, attenuates SHH signaling, and impairs axonal regrowth. Restoring SHH activity partially rescues neuronal structural deficits, highlighting the TTBK2/cilium–SHH as a therapeutic target.
Renfeng Zhang, Su Pan, Zhenwei Tian, Haorui Du, Jintao Wang, Xiaoyu Yang, Zhiping Qi   +6 more
wiley   +1 more source

Rho Small GTPase Family in Androgen-Regulated Prostate Cancer Progression and Metastasis. [PDF]

Cancers (Basel)
Hairston DWS, Mudryj M, Ghosh PM.
europepmc   +1 more source

Nobiletin Ameliorates Aβ1–42‐Induced Cognitive Disorder and Mitochondrial Dysfunction via Targeting the Key Circadian Regulator Bmal1

Food Safety and Health, Volume 4, Issue 1, Page 112-124, January 2026.
Nobiletin (NOB) ameliorates Aβ‐induced Alzheimer’s pathology by restoring circadian rhythm via Bmal1. NOB rescues cognitive deficits, synaptic damage, and mitochondrial dysfunction in mice and neurons by enhancing Bmal1/Clock oscillations and downstream mitochondrial integrity, positioning circadian regulation as a therapeutic target for Alzheimer's ...
Huajing Gao, Qinglin Qu, Ning Wang, Xue Gao, Peihua Li, Yanquan Mou, Xiangrui Kong, Yannan Chen, Dapeng Li, Xintong Tan   +9 more
wiley   +1 more source