Results 331 to 340 of about 123,069 (394)

A novel function of RHOA as a host-dependent factor in Glaesserella parasuis infection of LLC-PK1 cells. [PDF]

Vet Res
Zhou H, Chen X, Zeng X, Xie S, Zhang X, Zeng J, Xu K, Yu B, Liu H, Chen H.   +9 more
europepmc   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Insights into Nodal T-Follicular Helper Cell lymphomas and Peripheral T-Cell Lymphomas, Not Otherwise Specified, in Slovenian Patients: Mutational Landscape, Clinicopathological Characteristics, and Outcomes. [PDF]

Ann Hematol
Erzar E, Sindi-Ivanova V, Dirnhofer S, Boltežar L, Ocvirk J, Kloboves Prevodnik V, Tzankov A, Gašljević G.   +7 more
europepmc   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

KHSRP-mediated decay of axonally localized prenyl-Cdc42 mRNA slows nerve regeneration. [PDF]

PLoS Genet
Zdradzinski MD, Vaughn LS, Matoo S, Trumbull K, Smith TP, Noblitt D, Buchanan CN, Loomis A, Thames E, Lee SJ, Perrone-Bizzozero N, Lu Q, Larsen JM, Twiss JL.   +13 more
europepmc   +1 more source

Lenalidomide and Pomalidomide Meet RhoA

The Hematologist, 2009
openaire   +1 more source

Identification of actionable targets using DEPArray‐based sorting of pure carcinoma and stromal populations from formalin‐fixed paraffin‐embedded tissues followed by shallow whole‐genome sequencing

The Journal of Pathology, Volume 268, Issue 1, Page 13-26, January 2026.
Abstract Formalin‐fixed paraffin‐embedded (FFPE) tissue specimens represent precious resources for clinical genomic profiling studies, especially when coupled with comprehensive medical records. Even though next‐generation sequencing (NGS) is an effective tool to detect somatic mutations and somatic copy number alterations (sCNA), the biggest ...
Georgios Nteliopoulos, Evie Wren, Amelia Rushton, Marc K Wadsley, Daniel Fernandez‐Garcia, Floriana Manodoro, Otis Agbaimoni, Ritika Chauhan, Zhao Cheng, Darren P Ennis, Karen Page, Rebecca C Allsopp, Joel Bautista, Ignazio Puccio, Nik Matthews, Kelly LT Gleason, Rehman Farah, Laura Kenny, Iain A McNeish, Jacqueline A Shaw, R Charles Coombes   +20 more
wiley   +1 more source

The role of ANLN in malignant tumors: pathogenesis, treatment resistance and targeted strategies. [PDF]

Front Cell Dev Biol
Wang Y, Xiao Y, Yu J, Zou Y, Wang Z, Yang X.   +5 more
europepmc   +1 more source

Phosphorylation induces altered protonation states and allosterically regulates Rac1–RhoGDI complex

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Rho GTPases, critical for cellular functions like motility, are sequestered in an inactive GDP‐bound state by RhoGDI. While site‐specific RhoGDI phosphorylation is known to trigger selective GTPase release, the precise mechanisms remain elusive.
Krishnendu Sinha, Amit Kumawat, Hyunbum Jang, Ruth Nussinov, Suman Chakrabarty   +4 more
wiley   +1 more source

Divergent Morphologies and Common Signaling Features of Active and Inactive Oncogenic <i>RHOA</i> Mutants in Yeast. [PDF]

Cells
Wang C, Ohnuki S, Savchenko A, Aburatani H, Yoshida S, Hatakeyama R, Ohya Y.   +6 more
europepmc   +1 more source