Results 341 to 350 of about 123,069 (394)

Spatial Transcriptomic Characteristics of the Aging Human Ovary

Aging Cell, Volume 25, Issue 1, January 2026.
Troughing constructing a comprehensive spatiotemporal aging atlas on young and aged human ovaries, we revealed distinct cell types, cellular interactions, and aging‐associated gene expression changes due to aging. Specially, we detected an increase in DLK1:NOTCH3 expression which may contribute to the dysregulation of ovarian functions.
Meiling Zhang, Fanghao Guo, Qing Zhang, Qianhui Hu, Di Sun, Yongjian Ma, Yanquan Li, Mengxi Guo, Haixia Ding, Ying Guo, Baicai Yang, Songmao Li, Ningxia Sun, Yuxuan Zheng, Wen Li   +14 more
wiley   +1 more source

RhoA allosterically activates phospholipase Cε via its EF hands. [PDF]

Commun Biol
Ohri V, Samassekou K, Muralidharan K, Garland-Kuntz EE, Fisher IJ, Hogan WC, Davis BM, Lyon AM.   +7 more
europepmc   +1 more source

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

Tongjiang Hewei Decoction Improves Airway Hyperresponsiveness in Gastroesophageal Reflux Cough by Inhibiting ADAM33 and Epac1/Rap1 Pathway. [PDF]

Food Sci Nutr
Zhang X, Li X, Cheng Y, Wei L, Liu F, Li L, Zhang W, Yan X.   +7 more
europepmc   +1 more source

Arecoline upregulates CD155 expression to facilitate immune evasion in oral squamous cell carcinoma. [PDF]

J Immunother Cancer
Wang Q, Meng Y, Liu Y, Zhang S, Wang Y, Chen P, Xiang B, Zhou M, Gong Z, Zeng Z, Ge J, Xiong W.   +11 more
europepmc   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

P2Y14 receptor activation and neutrophil signaling: linking inflammation to systemic pathophysiology. [PDF]

Purinergic Signal
da Silva Ebone R, Doleski PH, Jantsch MH, da Silveira RP, Leal DBR.   +4 more
europepmc   +1 more source

RhoA controls myofibroblast characteristics

, 2018
Jatho, Aline, Kittana, Naim, Zimmermann, Wolfram-Hubertus, Lutz, S.   +3 more
openaire   +1 more source

Cinnamaldehyde Inhibits Leptin-Induced MMP-1 by Modulating Leptin Receptor/STAT3 and Blocking RhoA/NF-κB Pathways in Human Intervertebral Disc Stem Cells. [PDF]

Int J Mol Sci
Hua KF, Yu HC, Hsu HT.
europepmc   +1 more source

Chinese massage therapy (Tuina) inhibits motor neuron apoptosis in rats with sciatic nerve injury by regulating the cPLA2 and RhoA/ROCK2 signaling pathways

Jiawei Sun, Yingqi Zhang, Zhifeng Liu, Hanyu Zhang, Jiayue Liu, Yue Xu, Rong Na, Hongzheng Zhang, Jun Yan, Tianyuan Yu   +9 more
openalex   +1 more source