Results 361 to 370 of about 123,069 (394)
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Electrophoresis, 1999
Several algorithms have been described in the literature for protein identification by searching a sequence database using mass spectrometry data. In some approaches, the experimental data are peptide molecular weights from the digestion of a protein by ...
D. Vallois +7 more
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Several algorithms have been described in the literature for protein identification by searching a sequence database using mass spectrometry data. In some approaches, the experimental data are peptide molecular weights from the digestion of a protein by ...
D. Vallois +7 more
semanticscholar +1 more source
Biochemistry, 2006
We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release. We now show that the reaction of RhoA with redox agents leads to different functional consequences from that of Rac1 and Cdc42 due
Jongyun, Heo +3 more
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We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release. We now show that the reaction of RhoA with redox agents leads to different functional consequences from that of Rac1 and Cdc42 due
Jongyun, Heo +3 more
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Cytoskeleton, 2020
AbstractRecent evidence suggest that dysregulation of the tumor suppressor P53, in combination with disharmonious activities of the small GTPase RhoA, may lead to irreversible progression of human disease. The purpose of the present study is to communicate the most recent information regarding the highly interrelated P53/RhoA network.
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AbstractRecent evidence suggest that dysregulation of the tumor suppressor P53, in combination with disharmonious activities of the small GTPase RhoA, may lead to irreversible progression of human disease. The purpose of the present study is to communicate the most recent information regarding the highly interrelated P53/RhoA network.
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RhoA and resistance artery remodeling
American Journal of Physiology-Heart and Circulatory Physiology, 2005Resistance arteries are able to adapt to physiological and pathophysiological stimuli to maintain adequate perfusion according to the metabolic demand of the tissue. Although vasomotor control allows rapid adaptation of lumen diameter, vascular remodeling constitutes an active process that occurs in response to long-term alterations of hemodynamic ...
Gervaise, Loirand +2 more
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Inhibition of RhoA by p120 catenin
Nature Cell Biology, 2000RhoA organizes actin stress fibres and is necessary for cell transformation by oncogenes such as src and ras. Moreover, RhoA is implicated in cadherin clustering during the formation of adherens junctions. The catenin p120 has also been implicated in cadherin clustering through an unknown mechanism.
P Z, Anastasiadis +6 more
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Nuanced junctional RhoA activity
Nature Cell Biology, 2012RhoA signalling controls many diverse cellular processes, and thus discovering the mechanisms that determine its specific outcomes is a tantalizing challenge. A previously uncharacterized regulatory module operates selectively at the zonula adherens of epithelial cell junctions, in which positive and negative RhoA regulators are coordinated to fine ...
Swapnil S. Kher, Rebecca A. Worthylake
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RhoA inactivation enhances endothelial barrier function
American Journal of Physiology-Cell Physiology, 1999The modulation of endothelial barrier function is thought to be a function of contractile tension mediated by the cell cytoskeleton, which consists of actomyosin stress fibers (SF) linked to focal adhesions (FA). We tested this hypothesis by dissociating SF/FA with Clostridium botulinum exoenzyme C3 transferase (C3), an inhibitor of the small GTP ...
J M, Carbajal, R C, Schaeffer
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Activated RHOA and peripheral axon regeneration
Experimental Neurology, 2008The regeneration of adult peripheral neurons after transection is slow, incomplete and encumbered by severe barriers to proper regrowth. The role of RHOA GTPase has not been examined in this context. We examined the expression, activity and functional role of RHOA GTPase and its ROK effector, inhibitors of regeneration, during peripheral axon outgrowth.
C, Cheng +9 more
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Molecular and Cellular Neuroscience, 2005
Relatively little is known about the relationship between cellular lipid composition and the ability of neuroblasts to elaborate axonal and dendritic processes. We have studied the role of cholesterol and non-sterol isoprenoids during neurite outgrowth in PC-12 cells using inhibitors of cholesterol biosynthesis that act at different points in the ...
Carlos, Fernández-Hernando +2 more
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Relatively little is known about the relationship between cellular lipid composition and the ability of neuroblasts to elaborate axonal and dendritic processes. We have studied the role of cholesterol and non-sterol isoprenoids during neurite outgrowth in PC-12 cells using inhibitors of cholesterol biosynthesis that act at different points in the ...
Carlos, Fernández-Hernando +2 more
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1995
Abstract Rho sequences were originally isolated from an Aplysia cDNA library and used to identify three distinct, but highly homologous human sequences (Madaule and Axel 1985). The complete sequence of one of these, RhoA (originally called clone 12) (Yeramian et al. 1987), is shown in Fig. 1. The GenBank accession number is X05026.
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Abstract Rho sequences were originally isolated from an Aplysia cDNA library and used to identify three distinct, but highly homologous human sequences (Madaule and Axel 1985). The complete sequence of one of these, RhoA (originally called clone 12) (Yeramian et al. 1987), is shown in Fig. 1. The GenBank accession number is X05026.
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