Results 161 to 170 of about 2,906 (266)

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen   +15 more
wiley   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

open access: yesAdvanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn   +12 more
wiley   +1 more source

A Remarkable Tale: Increased Retinal Fluorescence Following Application of Permanent Marker Ink to Mouse Tails. [PDF]

open access: yesInvest Ophthalmol Vis Sci
Foshe S   +9 more
europepmc   +1 more source

Interfacial Proton‐Relay Microenvironment Enables Self‐Driven Singlet Oxygen Generation under Neutral Conditions

open access: yesAdvanced Science, EarlyView.
An interfacial proton‐relay microenvironment at MoS2‐CuCl heterostructures enables selective O2 activation to 1O2 under neutral conditions. Electron‐deficient sulfur sites mediate proton transfer to Cu‐bound O2, accelerating *OOH hydrogenation while suppressing O─O bond cleavage, achieving stable, efficient pollutant removal.
Qiaoyu Gao   +9 more
wiley   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao   +19 more
wiley   +1 more source

3D Interconnected Zn‐Ion Pathways Through Anionic Nanochannels Surrounding Bacterial Cellulose Nanofibers by Repetitive Interfacial Assembly for Aqueous Zn‐Ion Battery Separators

open access: yesAdvanced Energy Materials, EarlyView.
A repetitive interfacial assembly method is introduced to prepare a nanofibrillar separator with interconnected 3D anionic nanochannels for aqueous zinc‐ion batteries. The carboxylate‐rich nanochannels promote enhancements of Zn2+ ion transport and charge transfer at the electrode surface, and the 3D nanostructured hydrogels contribute to homogeneous ...
Wonseok Choi   +6 more
wiley   +1 more source

Optimized Properties and Synthesis of Photoactivatable Diazoketorhodamines Facilitate and Enhance High-Throughput Single-Molecule Tracking. [PDF]

open access: yesJ Org Chem
Pino NW   +14 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy